http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1492446-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_76195fd1cd08192222699d8e7a88c231 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-16 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J71-001 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J21-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J71-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-385 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-013 |
| filingDate | 1975-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1977-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1492446-A |
| titleOfInvention | 4,5-secopregnane derivatives |
| abstract | 1492446 4,5-Seco-pregnanes E R SQUIBB & SONS Inc 15 May 1975 [8 Nov 1974] 20694/75 Headings C2C and C2U The invention comprises compounds of formula (wherein A is -CH = CH 2 , -CH 2 CH 3 or -COCH 3 ; X 1 is H, Cl, Br or F; R 1 is H, OH, OCOR 4 , Cl, F, Br or I; R 2 is H or COR 4 ; R 3 is H, Me or CH 2 ; R 4 is C 1-7 alkyl, phenyl, or phenyl substituted by halo, alkyl or alkoxy; Y is H, Y<SP>1</SP> is OH or Y + Y<SP>1</SP> = oxo); and their preparation from compounds of formula (wherein X 2 is H or F) by hydration or complete or partial hydrogenation of the acetylenic bond, followed when required by one or more steps selected from: hydrolysis of ester groups; esterification of hydroxyl groups; sulphonation of a 21-hydroxyl group (steroid numbering) followed by reaction with an alkali metal halide (for I; R 1 = halo) or with NaI/glacial AcOH (for I; R 1 =H), and dehydration of a 9α-H-11#-OH compound followed by hydroxyhalogenation of the resulting 9(11)-ene. Compounds VIII supra are obtained from compounds of formula by reaction with p-toluenesulphonylhydrazide, optionally followed by conversion of a compound to a 9α-halo-11#-OH compound via a 9(11)-ene. Intermediates in the above reactions are 21 - mesyloxy - 9 - fluoro - 11#,17 - dihydroxy- 4,5-secopregnane-5,20-dione and 17,21-diacetoxy - 4,5 - secopregn - 9(11) - en - 3 - yne - 5,20- dione. 9 - Fluoro - 11#,17,21-trihydroxypregn - 4 -ene- 3,20-dione#its 11,21-(methyl orthoacetate)# the 17,21-(methyl orthoacetate) of 4#,5-epoxy-9-fluoro- 11#,17,21 - trihydroxy - 5# - pregnane - 3,20- dione (X)# the 17-acetate of X# the 17,21- diacetate of X. Oral antiinflammatory compositions comprise a compound I and a carrier. |
| priorityDate | 1974-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.