http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1491020-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5929f2d6f4dba84be8dd3a8ba633db12 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-36 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-34 |
| filingDate | 1974-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1977-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1491020-A |
| titleOfInvention | Intermediates for use in preparation of cephalosporin derivatives |
| abstract | 1491020 Cephalosporin derivatives TAKEDA YAKUHIN KOGYO KK 20 Dec 1974 [25 Dec 1973 20 Feb 1974 15 April 1974 17 July 1974 13 Nov 1974] 09056/77 Divided out of 1491018 Heading C2C Novel compounds I (R<SP>3</SP> is selected from the groups in which R is -CF 3 , -NH 2 , -(CH 2 ) n P<SP>1</SP>, -S-(CH 2 ) n -P<SP>2</SP>, or -NHP<SP>3</SP>; P<SP>1</SP> is -COOH, -CONH 2 , morpholino, morpholinocarbonyl, 1-4 C alkylthio, 1-4 C alkylsulphonyl, 1-4 C alkoxy, 1-4 C alkylamino, di-(1-4 C alkyl) amino, CH 3 COO-, di-(1-4 C alkyl)amino carbonyl, or 1-4 C alkoxy-carbonyl; n is 1-4; P<SP>2</SP> is -OH, -COOH, -CONH 2 , -SO 3 H, morpholinocarbonyl, di-(1-4 C alkyl)amino, 1-2 C alkoxy, -COCH 3 , -OCOCH 3 , di-(1-4 C alkyl)aminocarbonyl, or 1-4 C alkoxy-carbonyl; P<SP>3</SP> is 1-4 C alkyl, 1-4 C alkoxy-carbonyl, di-(1-4 C alkyl)aminocarbonyl, 1-4 C hydroxyalkyl, 1-4 C sulphoalkyl, di-(1-4 C alkyl)amino-1-4 C alkyl-carbonyl or di-(1-4 C alkyl)amino-1-4 C alkyl; and R<SP>1</SP> is H or 1-2 C alkyl) and salts and esters thereof are prepared by deacylation of the reaction product of cephalosporin C and an appropriate thiol R<SP>3</SP>SH or by reaction of 7-protected aminocephalosporanic acid with R<SP>3</SP>SH, followed by deprotection. Intermediates isolated are potassium 3- (methylsulphonylacetyl)dithiocarbazinate; 2- methylsulphonylmethyl - 1,3,4 - thiadiazole - 5- thiol; 4 - (2 - hydroxyethyl) - thiosemicarbazide and 2 - (2 - hydroxyethylamino) - 1,3,4 - thiadiazole-5-thiol. |
| priorityDate | 1973-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.