http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1487712-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_95a226ec4ea362dc6021d03a6730a841 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S930-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-23 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-23 |
| filingDate | 1976-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1977-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1487712-A |
| titleOfInvention | Lh and fsh releasing peptide amides |
| abstract | 1487712 LHRH-releasing peptides ICI AUSTRALIA Ltd 8 April 1976 [15 April 1975] 14370/76 Heading C3H A peptide of formula H-Pyroglu-His-Trp-Ser-Tyr-X-Y-Arg-Pro-Z wherein (1) if X is Gly; Y is Leu and Z is #- Ala-NH 2 or Sar-NH 2 ; (2) if X is D-Ala: Y is Leu, Nle, Ile, Val, Nva or Met and Z is Gly- NH 2 , #-Ala-NH 2 or Sar-NH 2 provided that, when Y is Leu, Z is not Gly-NH 2 ; (3) if X is #-Ala, Y is Leu, Nle, Ile, Val, Nva or Met and Z is Gly- NH 2 , #-Ala-NH 2 , Sar-NH 2 or NRR<SP>1</SP> wherein R and R<SP>1</SP>, which may be the same or different, are hydrogen, C 1 -C 6 alkyl which may be substituted; or R and R<SP>1</SP> taken with the nitrogen atom, may form a ring; or a pharmaceuticallyacceptable acid addition salt or pharmaceutically-acceptable metal ion complex thereof. The peptides may be prepared by solid phase synthesis, preferably on a pellicular graft copolymer support. In the Examples, the polymer support is polystyrene grafted onto polychlorotrifluoroethylene and is substituted by (1)-(5) benzhydrylamino groups; (6)-(9) chloromethyl groups; and the peptides prepared are: Pharmaceutical compositions, which may be used to promote maturation of egg folicles and induce ovulation in non-human female mammals, comprises the peptides, the pharmaceutically-acceptable acid addition salts or pharmaceutically-acceptable metal ion complexes thereof, in admixture with a pharmaceuticallyacceptable carrier therefor. The compositions may be sterile saline solutions, which may be administered by infusion or by intravenous injection. |
| priorityDate | 1975-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 19.