http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1479189-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_76195fd1cd08192222699d8e7a88c231 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23K1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 1974-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1977-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1479189-A |
| titleOfInvention | Benzodiazepine derivatives |
| abstract | 1479189 Triazinobenzodiazepines E R SQUIBB & SONS Inc 28 Aug 1974 [5 Oct 1973] 37616/74 Heading C2C Compounds of the general formula (R 1 =H, alkyl, Ph, PhCH 2 ; R 2 =H, alkyl; R 3 =H, R 4 (CH 2 ) 2-4; R 4 =NH 2 , alkylamino, dialkylamino or A=CHQ, O, NQ; Q=H, alkyl; m=0, 1; R 5 =H, halogen, NO 2 , CN, CF 2 alkyl, alkoxy, alkylthio) and their acid addition salts are prepared by reacting a compound of the formula (R 6 = halogen, SH, alkoxy, alkylthio, phenalkylthio; R 7 =alkyl, Ph, PhCH 2 ) with morpholinoglyoxylhydrazide, or with tert.-butyl or benzyl (optionally alkoxy or nitro substituted) carbazate followed by reaction with an oxalic acid ester, an alkanol and an anhydrous acid, optionally followed by introduction of the 2-substituent (e.g. via the Tl derivative), removal of the benzyl group and/or salt formation. The 2-unsubstituted compounds are central nervous system depressants, and the 2-substituted compounds are anti-inflammatory agents. They may be administered in the form of pharmaceutical or veterinary preparations containing them in association with a carrier. |
| priorityDate | 1973-10-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 20.