http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1478932-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4c4cb9b5558ad97d3acc0db1113f7727 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-10 |
| filingDate | 1975-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1977-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1478932-A |
| titleOfInvention | 8-(3-chromanyl)-1-oxa-3,8-diazaspiro(4,5)decan-2-ones and thiones |
| abstract | 1478932 8 - (3 - Chromanyl) - 1 - oxa- 3,8 - diazaspiro(4,5)decan- 2 - ones and thiones SCIENCE UNION ET CIE SOC FRANCAISE DE RECHERCHE MEDICALE 5 March 1976 [6 March 1975] 9356/75 Heading C2C Novel compounds of the Formula I wherein R 1 is hydrogen, fluorine, or C 1-5 .alkyl, R 2 is hydrogen, methyl or ethyl, R 3 is hydrogen or C 1-4 alkyl and X is oxygen or sulphur and acid addition salts and also base-addition salts when X is sulphur may be prepared by (1) reacting a 3-chromanone II with a spiro-decane III and hydrogenating the resulting enamine IV (II) reacting a compound V with a carbonic or thiocarbonic acid derivative, or (III) when X is oxygen submitting a hydrazide VI to a Curtius rearrangement, the product of which cyclises in situ. 1 (3 - Chromanyl) - 4 - aminomethyl 4- piperidinol is prepared by forming 1-(3-chromanyl) - 4 - cyano - 4 - piperidinol from 1- (3 - chromanyl) - 4 - piperidone and thereafter hydrogenating the cyanohydrin. [1 - (3 - Chromanyl) - 4 - hydroxy - 4 - piperidyl] acethydrazide is prepared by reacting 1-(3- chromanyl) - 4 - piperidone in Reformatsky reaction to form ethyl[1 - (3 - chromanyl)- 4 - hydroxy - 4 - piperidyl] acetate followed by reaction with hydrazine. Pharmaceutical compositions of the compounds I or physiologically acceptable salts thereof with the usual excipients show bronchodilatory and anti-anaphylactic properties when administered orally, parenterally or rectally. |
| priorityDate | 1975-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.