http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1476124-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_76195fd1cd08192222699d8e7a88c231 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C309-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-42 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N43-90 |
| filingDate | 1974-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1977-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1476124-A |
| titleOfInvention | Fused-ring benzoxadiazepine and benzoxadiazocine derivatives |
| abstract | 1476124 Pyrimidino - benzoxadiazepine and -benzoxadiazocine compounds and intermediates therefor E R SQUIBB & SONS Inc 3 July 1974 [26 July 1973] 29533/74 Heading C2C Novel pyrimidinobenzoxadiazepine or pyrimidinobenzoxadiazocine compounds of the Formula I wherein m is 1 or 2, n is 0 or 1, R<SP>11</SP> is a hydrogen atom or a C 1-4 alkyl group, R is a hydrogen, fluorine, chlorine or bromine atom or a C 1-4 alkyl, benzyl, phenyl or monosubstituted phenyl group, the substituent being halogen, C 1-4 alkyl, C 1-4 alkoxy or trifluoromethyl, and R<SP>1</SP> is a hydrogen or halogen atom or a C 1-4 alkyl, C 1-4 alkylsulphonyl, di(C 1-4 alkyl)sulphamoyl or trifluoromethyl group, provided that when m is 1, R occupies either position-4- or -5 of the pyrimidine ring, but when R is halogen it occupies only position-5 and when m is 2 the two R's occupy the 4- and 5- positions of the pyrimidine ring, but only one of the R's can be halogen and it must occupy the 5-position, are obtained by cyclizing compounds of the Formula IV or V in which X is a chlorine or bromine atom. Compounds of the Formula IV above may be obtained by reacting appropriate 2-aminopyrimidines with appropriate haloalkyl obromophenyl ethers. Compounds of the Formula V above may be obtained by treating compounds of the Formula IV with a water-miscible alcohol and an alkalimetal C 1-3 alkoxide. o-Bromo-α-chloroanisole may be obtained by reacting sodium bromomethane sulphonate with o-bromophenol and chlorinating the (o-bromophenoxy)methanesulphonic acid, sodium salt so obtained. 2 - Bromo - 5 - chlorophenyl chlorophenyl ether may be obtained analogously via 2- bromo-5-chlorophenoxymethane sulphonic acid, sodium salt. 2-Chloropropyl o bromophenyl ether may be obtained by reacting 1-bromo 2- chloropropane with o-bromophenol. Sodium bromomethane sulphonate may be obtained by reacting dibromomethane with sodium sulphite. Pharmaceutical compositions comprise compounds of Formula I as active ingredients. |
| priorityDate | 1973-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.