http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1473169-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D219-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D219-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D219-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D219-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D219-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P33-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-473 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 |
| filingDate | 1974-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1977-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1473169-A |
| abstract | 1473169 Acridones HOECHST AG 24 July 1974 [24 July 1973] 32682/74 Heading C2C The invention comprises compounds of Formula I in which R<SP>1</SP> represents an oxygen atom or a hydrazone radical =N-NH 2 , R<SP>1</SP> to R<SP>7</SP>, which may be identical or different, each represents a hydrogen atom, a straight or branched chain, saturated or unsaturated, lower (=C 1 -C 6 ) alkyl radical, a phenyl group which may have up to three identical or different substituents selected from fluorine, chlorine, bromine and iodine atoms and trifluoromethyl, nitro, cyano, carbamyl, sulphamyl, acetyl, lower alkyl-sulphoxy and phenyl-sulphoxy, lower alkylsulphonyl and phenyl-sulphonyl, lower alkoxy and methylenedioxy groups, with the proviso that not more than one of the radicals R<SP>2</SP> to R<SP>7</SP> represents an aromatic radical, R<SP>8</SP> to R<SP>11</SP>, which may be identical or different, each represents a hydrogen, fluorine, chlorine, bromine, or iodine atom or a trifluoromethyl, cyano, lower alkyl, or lower alkoxy group, R<SP>12</SP> represents a hydrogen atom, a hydroxyl group, or a straight or branched chain lower acyloxy group. The compounds form salts with acids and bases. Compounds of Formula I are prepared by reacting a 2-nitrobenzaldehyde (II) with a 1,3- cyclohexanedione (III) in a water-miscible solvent (e.g. acetic acid) in the presence of a mineral acid (e.g. HCl or HBr) at up to 120 C., and if desired, and in any order, subsequently (a) converting R<SP>1</SP> from = CO to =N-NH 2 by reacting with hydrazine, (b) reducing, e.g. with PCl 3 , to convert R<SP>12</SP> from -OH to -H, or (c) reacting with acid halide R<SP>13</SP>COhal or anhydride R<SP>13</SP>CO.O.CO.R<SP>13</SP> (R<SP>13</SP>= lower alkyl) to convert R<SP>12</SP> from -OH to -CO-R<SP>13</SP>. When using II in which the 5- position is unsubstituted, with HCl (HBr) a Cl (Br) atom is introduced into the 7-position (R<SP>10</SP>) of the product; if the 5-position is substituted, it is of advantage to add a reducing agent to the reaction mixture (e.g. hydroquinone, pyrogallol, oxyhydroquinone or ascorbic acid) to prevent further introduction of halogen. Compounds of Formula I are chemotherapeutic agents. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9702034-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-000632-B1 |
| priorityDate | 1973-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.