http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1472746-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_232361c9031a709144573276863c462b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07G- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- |
| filingDate | 1973-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1977-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1472746-A |
| titleOfInvention | Cephalosporin compounds |
| abstract | 1472746 Cephalexin solvate GLAXO LABORATORIES Ltd 14 June 1974 [5 July 1973] 32111/73 Heading C2C A bis-dimethyl formamide solvate of cephalexin is produced by (a) acylating a silylated derivative of 7-aminodesacetoxy cephalosporanic acid (7-ADCA) by reaction with phenyl glycyl chloride hydrochloride in dimethyl formamide at a temperature not exceeding 0‹ C. in the presence of a tertiary nitrogen base having a pKa in the range 3À0-7À0 and (b) precipitating the cephalexin product so formed as a bisdimethyl formamide solvate by diluting the reaction solution with water and adjusting the pH to about 6À9 by addition of a base. Bases used in (a) include pyridine, quinoline and homologues and/or substituted derivatives thereof. After the acylation (a), the resulting solution may be treated with a compound containing active hydrogen, e.g. water, an alcohol or phenol, to remove any silyl groups present in the cephalexin reaction product before step (b). Silylated derivatives of 7-ADCA may be prepared using as silylating agent a halosilane or a silazane. |
| priorityDate | 1973-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.