http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1467407-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3e9445e5e3626f36e932c6451a928250 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-20 |
| filingDate | 1974-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1977-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1467407-A |
| titleOfInvention | Process for the manufacture of 7-beta-acylaminoceph-3-em- 4-carboxylic acid compounds |
| abstract | 1467407 7 - Acylamino - ceph - 3 - em - 4- carboxylic acids and derivatives thereof CIBAGEIGY AG 28 March 1974 [30 March 1973] 13720/74 Heading C2C Novel compounds of the Formula I wherein X is sulphur or oxygen, R is hydrogen or an amino protective group, R 1 is hydrogen, a free etherified or esterified hydroxyl or mercapto group, or a substituted ammonium group, R 2 is hydroxyl or a carboxyl protective radical which together with the carbonyl grouping of the formula -C(: O)- forms a protected carboxyl group, or salts thereof, may be prepared by acylating a compound of the Formula II wherein the amino group is optionally substituted by a group which permits acylation to take place, or a salt thereof with carboxylic of the Formula III or a reactive derivative thereof and optionally removing or interconverting protective groups at R and R 2 , converting R 1 groups to other R 1 groups and forming salts or free compounds. 2 - (5 - N - tert. - Butoxycarbonylaminomethyl- 2-thienyl acetic acid is prepared by reacting thenylamine hydrochloride with trifluoroacetic acid and acetic anhydride to form 2-acetyl-5- trifluoroacetylaminomethyl-thiophene which with perchloric acid, thallium nitrate and methanol yields 2 - (5 - trifluoroacetylaminomethyl - 2- thienyl) acetic acid, methyl ester which with base and then t-butoxycarbonyl azide yields the required compound. 2-(5-N-t-Butoxycarbonylamino-2-furyl) acetic acid is prepared by an analogous process from furfurylamine. 2-Acetyl- 5 - trifluoroacetylaminomethyl - thiophene is also prepared by reacting thiophene with N- hydroxymethyltrifluoroacetamide in trifluoroacetic acid and acetic anhydride. Pharmaceutical compositions of the compounds I in which R is hydrogen and R 2 is hydroxyl or a radical which together with the carbonyl grouping of the formula -C(=O)- forms an esterified carbonyl group which can be split under physiological conditions or a physiologically acceptable salt thereof, with the usual excipients show antibiotic activity when administered orally or parenterally. |
| priorityDate | 1973-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 59.