http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1466710-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24aca9ded2638ea793d05360dde7a4a0 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D499-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-04 |
| filingDate | 1974-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1977-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1466710-A |
| titleOfInvention | Process for producing cephalosporin intermediates |
| abstract | 1466710 3-Methyl-7-amino-cephem-4-carboxylic acids SUMITOMO CHEMICAL CO Ltd 29 Nov 1974 [29 Nov 1973] 51912/74 Headings C2C and C2P A cephalosporanic acid derivative of the Formula (I) wherein R 2 is an H atom or an ester protective group, is produced by reacting a phosphoramide derivative of Formula (II) wherein R 1 is C 1-4 alkyl, with a phosphorus acid, including orthophosphoric acid, phosphorous acid, phosphonic acid or phosphinic acid and the esters and anhydrides thereof. 2,2,2 - Trichloroethyl - 6# - dimethyl - phosphoramidopenicillanate 1-oxide is obtained by reacting 2,2,2-trichloroethyl-6#-(phenyl-acetamido)-penicillanate 1-oxide with PCl 5 in the presence of dimethylaniline and subsequently treating with methanol; the product is heated in the presence of pyridinium dichloromethane phosphonate to yield 2,2,2-trichloroethyl-3- methyl - 7# - dimethylphosphoramido - 3 - cephem - 4 - carboxylate; phenacyl 6 - aminopenicillanate hydrochloride is reacted with dimethylchlorophosphate in the presence of triethylamine and further with m-chloroperbenzoic acid to give phenacyl 6#-dimethylphosphoramidopenicillanate 1-oxide which on heating with pyridinium dichloromethanephosphonate yields phenacyl 3-methyl-7#-dimethylphosphoramido - ceph - 3 - em - 4 - carboxylate; phenacyl 6# - dimethylphosphoramidopenicillanate - 1- oxide was also obtained by first forming phenacyl 6#-aminopenicillanate 1-oxide and reacting with dimethyl chlorophosphate in the presence of diethylaniline. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0018155-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0018155-A3 |
| priorityDate | 1973-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.