http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1464810-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c7ad58d3c0b071069a8ee0cb8c8ba2e8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D253-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D253-075 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D253-075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D253-06 |
| filingDate | 1975-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1977-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1464810-A |
| titleOfInvention | Process for the preparation of 6-tert-butyl-3-mercapto-4-amino- 1,2,4-triazin-5-4h-one |
| abstract | 1464810 6 - Tert. - butyl - 3 - mercapto - 4- amino - 1,2,4 - triazin - 5(4H) - one BAYER AG 17 Oct 1975 [21 Dec 1974] 42631/75 Heading C2C 6 - Tert. - butyl - 3 - mercapto - 4 - amino- 1,2,4-triazin-5(4H)-one of the formula is prepared by: (1) reacting pinacolone, of the formula with a sulphur chloride of the general formula wherein n is 1 or 2, at a temperature between 0 and 80 C., optionally in the presence of a diluent.; (2) reacting the reaction mixture directly, without further purification, with an aqueous solution of an amine of the general formula in which R and R<SP>1</SP>, which may be identical or different, are each hydrogen, alkyl with 1-8 carbon atoms, cycloalkyl with 5-6 carbon atoms or aryl which has 6-10 carbon atoms and which is optionally substituted by methyl or chlorine, or R and R<SP>1</SP> conjointly form a radical -(CH 2 ) m - (where m = 4, 5 or 6) or optionally in the presence of a diluent; (3) hydrolysing the tert.-butyl-glyoxyl-thioamide of the general formula wherein R and R<SP>1</SP> have the above-mentioned meanings, which is thus formed, without intermediate isolation by adding at least 2À5 moles of alkali metal hydroxide per mole of pinacolone (IV) and heating for 2-10 hours at 80-150 C., to give an alkali metal salt of 3,3-dimethyl-2- oxo-butyric acid of the formula wherein M is an alkali metal; (4) liberating 3,3- dimethyl - 2 - oxo - butyric acid of the formula from the salt (Ia) by acidification with a mineral acid; and (5) reacting the aqueous solution of 3,3 - dimethyl - 2 - oxobutyric acid, if' appropriate after filtering off any sulphur which may have precipitated on acidification, with thiocarbohydrazide of the formula In a modification, steps (2) and (3) above may be omitted and the reaction product of pinacolone and the sulphur chloride may be treated directly with the aqueous solution of the alkali metal hydroxide under the conditions specified for step (3) above, to give the alkali metal salt (Ia) which is then treated with acid to liberate the acid (I). |
| priorityDate | 1974-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.