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filingDate 1974-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1977-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber GB-1464401-A
titleOfInvention Aminoglycosides
abstract 1464401 Silylated aminoglycoside PFIZER Ltd 24 Oct 1975 [26 Oct 1974] 46412/74 Heading C3S [Also in Division C2] The penta - N - acetyl - octa - O - trimethylsilyl derivative of 1 - N - [(S) - 4 - amino - 2- hydroxybutyl] - kanamycin A is prepared by treating 1 - N - [(S) - 4 - amino - 2 - hydroxybutyl]-kanamycin A with acetic anhydride in methanol at room temperature for 24 hours, followed by a 2 : 1 mixture of hexamethyldisilazane and trimethylchlorosilane at room temperature for 24 hours.
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