http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1464288-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5deddb47ccaab1d4da2aacc344dd8717 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D243-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D243-04 |
| filingDate | 1974-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1977-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1464288-A |
| titleOfInvention | Fused ring indole derivatives |
| abstract | 1464288 Derivative of 1,3-diazepino[1,2-a]indole JOHN WYETH & BRO Ltd 6 Dec 1974 [5 March 1974] 9762/74 Addition to 1366133 Heading C2C The invention comprises 11-(m-chlorophenyl)- 2,4,5,11 - tetrahydro - 3H - [1,3] - diazepino- [1,2-a]indol - 11 - ol(A) and its pharmaceutically acceptable acid addition salts, and processes for preparing it by (1) cyclodehydrating 1-(4- aminobutyl) - 3 - (m - chlorophenyl) - 3 - hydroxy- 2 - indolinone [which is itself made by reducing the 1-(3-cyanopropyl)analogue], or (2) reacting 2,4,5,11 - tetrahydro - 3H- [1,3] - diazepino[1,2a]- indol-11-one with m-ClC 6 H 4 Mg-halide. Also mentioned are the 11-Ph and 9-Cl-11-o-ClC 6 H 4 analogues of compound (A). Starting materials otherwise prepared have the formula o-BrC 6 H 4 CH(OH)Z and o-BrC 6 H 4 COZ, where Z is 4,5,6,7-tetrahydro- 1,3-diazepinyl. Therapeutic compositions having antidepressant activity comprise the above product (A) and may be administered orally or parenterally. |
| priorityDate | 1974-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 20.