http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1453890-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c902faf6ae746c51fc8010672fc22894 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C405-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-935 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C401-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C405-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-935 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 |
| filingDate | 1974-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1976-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1453890-A |
| titleOfInvention | Prostaglandin intermediates |
| abstract | 1453890 Prostaglandin intermediates UPJOHN CO 11 Nov 1974 [12 Nov 1973] 03707/76 Divided out of 1453889 Heading C2C The invention comprises optically active prostaglandin intermediates of the formulµ or racemates thereof, wherein E is or in which R 2 is H or C 1-4 alkyl; and R 1 is -CR 3 R 4 -(CH 2 ) n -CH 3 or in which R 3 and R 4 each are H, F or C 1-4 alkyl, with the proviso that -CR 4 R 4 - is not n is 1 to 5; -CmH 2 mis a valence bond or C 1-9 alkylene, with 1 to 6 carbon atoms in the chain between -CH 2 - and the ring; T is C 1-4 alkyl, C 1-4 alkoxy, OH, F, Cl or CF 3 , s is 0 to 3, provided that when s is 2 or 3 the T's may be the same or different and that not more than two T's are other than alkyl; E 1 is or in which R 5 is 2-tetrahydrofuronyl, 2-tetrahydropyronyl, or a group of the formula in which R 6 is C 1-18 alkyl, C 3-10 cycloalkyl, C 7-12 aralkyl, or phenyl optionally substituted by 1 to 3 C 1-4 alkyl radicals, either R 7 and R 8 are H, C 1-4 alkyl, phenyl optionally substituted with 1 to 3 C 1-4 alkyl radicals or R 7 and R 8 taken together are -(CH 2 ) a or in which a is 3, 4 or 5, b is 1, 2 or 3, and c is 1, 2 or 3 with the proviso that d+c is 2, 3 or 4, and R 9 is H or phenyl; with the further proviso that E is not α-hydroxy when R 1 is n-pentyl and R 2 is H. The compounds are prepared by known methods. The following intermediates are prepared: 2 - formyl - 5α - hydroxy - 2 - cyclopentene- 1α-acetic acid γ-lactone, 5α-hydroxy-2-(3(5)- hydroxy - trans - 1 - octenyl) - 2 - cyclopentene- 1α-acetic acid γ-lactone, and compounds of the above formula in which E is an oxo radical and R 1 is n-pentyl, 1-methylpentyl, 1,1-dimethylpentyl, 1-fluoropentyl, 1,1-difluoropentyl, phenethyl, p-chlorophenethyl and 2-(o-tolyl)ethyl. |
| priorityDate | 1973-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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