http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1453667-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_94ff2d78578d95d1e8d3a2233c76188d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2121-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-3839 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0489 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04 |
| filingDate | 1974-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1976-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1453667-A |
| titleOfInvention | Radionuclide-labelled phosphonic acids for the treatment of calcific tumours |
| abstract | 1453667 Anti-tumour compositions PROCTER & GAMBLE CO 22 May 1974 [23 May 1973] 22847/74 Heading A5B [Also in Division C2] Calcific tumours in animals are treated by administering to the animal a safe but effective amount of a phosphonate, tagged with a <SP>32</SP>p or <SP>33</SP>P radionucleide, selected from compounds of the formulae:- where each R is H or CH 2 OH and n is 3 to 10; where R 1 is H, C 1-20 alkyl, C 2-20 alkenyl, aryl, phenylethenyl, benzyl, halogen, OH, NH 2 , substituted amino, -CH 2 COOH, -CH 2 PO 3 H 2 , -CH(PO 3 H 2 )(OH) or -[CH 2 C(PO 3 H 2 ] n -H, where n is 1 to 15,. and R 2 is H, alkyl, NH 2 , benzyl, halogen, OH, -CH 2 COOH,-CH 2 PO 3 H 2 or -CH 2 CH 2 PO 3 H 2 ; where n is 3 to 9; where each R 3 is H or alkyl; where n is 2 to 4; and (X) where X and Y are each H or OH; or a pharmaceutically acceptable salt of such a compound. A chemotherapeutic agent, selected from alkylating agents, antimetabolites, antibiotics, vinea alkaloids, hormones, enzymes, hydroxyurea and procarbazine, may be administered after the administration of the tagged compound. Specified chemotherapeutic agents are mechlorethamine hydrochloride, triethylenemelamine, thiotepa triethylenethiophosphoramide, bulsulfan, chlorambucil, cyclophosphamide, melphalan, BCNU, 6-mercaptopurine, DON, azaserine, methotrexate, 5-fluorouracil, cytarabine, actinomycin D, dactinomycin, mithramycin, daunomycin, nitomycin C, vinblastine sulphate and vincristine sulphate. Preferably the dosage level of the tagged compound is 0.2 to 20 millicuries. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-8907453-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2118042-A |
| priorityDate | 1973-05-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 57.