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filingDate 1974-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1976-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber GB-1450325-A
titleOfInvention Coating compositions for medicines
abstract 1450325 Coating compositions SHINETSU CHEMICAL CO 2 April 1974 [2 April 1973] 14545/74 Heading A5B [Also in Division C3] A composition useful for coating tablets so that the contents are released in the intestines and not the stomach comprises a mixture of (a) a cellulose derivative insoluble in gastric fluid but soluble in intestinal fluid, and (b) a cellulose derivative which is insoluble in both. Derivative (a) must have monoester linkages with a polybasic acid and examples are; hydroxypropylmethylcellulose phthalate, cellulose acetate phthalate, ethylcellulose phthalate, hydroxypropyl methyl cellulose succinate, cellulose acetate succinate, hydroxypropylmethyl cellulose hexahydrophthalate, cellulose acetate hexahydrophthalate and hydroxypropyl methyl cellulose trimellitate. Examples of (b) are ethyl cellulose, acetayl cellulose, nitrocellulose, cellulose acetate butyrate and cellulose acetate propionate. In Examples, tablets are prepared from KC1 plus gelatin and perhaps potassium stearate and from a mixture of aspirin and lactose. These tablets are coated with the above compositions.
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