http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1449802-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9ef09638d81ddcdad7c415a631d615b7 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-073 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-096 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-073 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-096 |
| filingDate | 1975-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1976-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1449802-A |
| titleOfInvention | Piperazine derivatives and compositions containing them for treating parkinsons disease |
| abstract | 1449802 N-(#-Naphthylmethyl)-piperazines SMITHKLINE CORP 3 Feb 1975 [7 Feb 1974] 4536/75 Heading C2C Novel N-(#-naphthylmethyl)-piperazines of the general formula wherein R is a phenyl, C-pyridyl or C-pyrimidinyl ring which is optionally substituted by C 1-5 alkyl, halogen, hydroxy or C 1-5 alkoxy and R 1 is hydrogen, C 1-5 alkyl, halogen, hydroxy or C 1-5 alkoxy, and pharmaceutically acceptable acid addition salts thereof are prepared by reacting a #-chloromethylnaphthalene and a piperazine of the general formulµ or by reacting the said #-chloromethylnaphthalene with piperazine and introducing the desired N<SP>4</SP>-substituent into the resulting N<SP>1</SP>-(R 1 - substituted - # - naphthylmethyl) - piperazine, followed optionally by salification of the product. R 1 - Substituted - # - chloromethylnaphthalenes are prepared by reducing the appropriate #- naphthoic acid with LiAlH 4 and chlorinating the resulting #-naphthalenemethanol. Pharmaceutical compositions having anti- Parkinsonism activity comprises, as active ingredient, a N-(#-naphthylmethyl)-piperazine of the first general formula above or pharmaceutically acceptable acid addition salt thereof, together with a pharmaceutical carrier. |
| priorityDate | 1974-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 24.