| abstract |
1449298 Tricyclic compounds F HOFFMAN-LA ROCHE & CO AG 7 June 1974 [8 June 1973] 13213/76 Divided out of 1449297 Heading C2C Compounds of the general formula (X = O, S; R 1 , 2 = H, C 1-7 alkyl; R 3 = H or R 2+3 = additional bond; R<SP>1</SP> 6 = halogen, CF 3 , OH, NO 2 , NH 2 , di(C 1-7 alkyl)amino, di(C 1-7 alkyl) sulphamoyl, C 1-7 alkyl, alkoxy, alkylthio or alkylsulphonyl, protected hydroxy; R 7 1, R 8 1 = H or a substituent listed for R 6 1) are prepared by standard methods, e.g. reacting the corresponding 10- one with trimethylsilylethynyl lithium followed by hydrolysis, dehydration and cleavage of the trimethylsilyl group. |