http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1449100-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2e5edd48190cba3fa70dd3975efd9831 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-557 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-54 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-557 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-50 |
| filingDate | 1974-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1976-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1449100-A |
| titleOfInvention | Pyrimidine derivatives processes for their preparation and their use in pharmaceutical compositions |
| abstract | 1449100 Pyrimidine derivatives DR KARL THOMAE GmbH 20 Aug 1974 [20 Aug 1973 26 June 1974] 36606/74 Heading C2C The invention comprises compounds of the general formula (wherein R 1 represents an alkoxy group containing 1 to 3 carbon atoms; a morpholino, thiomorpholino, 1-oxidothiomorpholino or 1,1- dioxidothiomorpholino group; or a piperazino group optionally substituted in the 4-position by an alkanoyl or alkenoyl group containing 1 to 4 carbon atoms (which itself is optionally substituted by a methoxy, carboxyl or acetyl group), by an aminocarboxyl group (which is itself optionally substituted by one or two alkyl groups containing from 1 to 4 carbon atoms or by a methoxymethyl group); by a pyridinoyl, salicyloyl or furanoyl group or by an alkylsulphonyl group containing from 1 to 3 carbon atoms; R 2 represents a morpholino, thiomorpholino, 1-oxidothiomorpholino or 1,1-dioxidothiomorpholino group; or a piperazino group optionally substituted in the 4-position by an alkanoyl group containing 1 to 3 carbon atoms which is itself optionally substituted by an acetyl group; R 3 represents a hydrogen, chlorine or bromine atom; or a nitro, cyano, formyl or acetyl group; and R 4 represents a hydrogen, chlorine or bromine atom; a cyano group; an amino group substituted by a cyclohexyl group, by a phenyl group optionally substituted by a chlorine atom or a carboxyl or carbomethoxy group, or by a pyridyl group; a carbalkoxy group containing 2 to 4 carbon atoms; an alkyl group containing 1 to 6 carbon atoms optionally substituted by one or two carbalkoxy groups containing 2 to 4 carbon atoms; a hydroxyl or mercapto group optionally substituted by an allyl group or by an alkyl group containing 1 to 6 carbon atoms; or a 1- oxidothiomorpholino group) and acid addition salts thereof. They may be prepared by reacting a compound of the formula where one or two of the groups X, Y and Z is a leaving group and the other(s) are as defined above for R 1 , R 2 and R 3 , with a compound of formula where A is as defined above for the appropriate group R 1 , R 2 or R 3 . The compounds of the invention may be used as active ingredients in pharmaceutical compositions. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6723723-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6225309-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6486154-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6313127-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6730672-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6391880-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6090813-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6093718-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6440972-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6300330-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6936610-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7173025-B1 |
| priorityDate | 1973-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 64.