http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1446791-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2e5edd48190cba3fa70dd3975efd9831 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-04 |
| filingDate | 1974-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1976-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1446791-A |
| titleOfInvention | 1,3-diketo-1,2,3,4-tetrahydroisoquinolines |
| abstract | 1446791 Substituted α-isoquinolin-2yl-#- piperazin-1-yl alkanes and their pharmaceutical compositions DR KARL THOMAE GmbH 6 Sept 1974 [8 Sept 1973 (2)] 39083/74 Heading C2C The invention comprises compounds of Formula I wherein R<SP>1</SP> represents a H or halogen atom or a OCH 3 or SCH 3 group; R 2 represents H or OCH 3 ; n represents 2 or 3 and A represents a group of Formula Ia or Ib wherein R 3 represents H or CH 3 ; R 4 represents an optionally methyl substituted pyridyl group or a phenyl group optionally substituted by a chlorine atom, CF 3 group or by one or two methyl, ethyl or methoxy groups and R 5 and R 6 independently represent H or OCH 3 and their physiologically acceptable acid addition salts which may be prepared by reaction of (a) a compound of Formula II or IIa wherein R 1 and R 2 are as defined above and B is an oxygen atom or an optionally substituted secondary amino group with a compound of Formula III wherein A and n are as defined above, or with an acid addition salt thereof; (b) a compound of Formula IV wherein R 1 , R 2 and n are as defined above and Z represents a group exchangeable with the group A with a compound of Formula V where A is as defined above or (c) a compound of Formula VI wherein R 1 and R 2 are as defined above, or a metal salt thereof, with a compound of Formula VII where A, n and Z are as defined above and optionally (d) converting a compound of Formula I into its acid additive salt in known manner. 2 - [2 - (3,4 - dimethoxyphenyl)ethylamine] - 1- cyanoethane is prepared by reaction of 2-(3,4- dimethoxyphenyl)-ethylamine with acrylonitrile and is reduced with hydrogen in methanolic ammonia and in the presence of Raney nickel to obtain 1-[2-(3,4-dimethoxyphenyl)-ethylamino]- 3-aminopropane. Pharmaceutical Compositions having bradycardiac, antiarrhythmic and sedative activity for oral, rectal or parenteral administration comprise at least one compound of Formula I or a physiologically compatible acid addition salt thereof together with a pharmaceutical carrier or excipient. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8338405-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-2702600-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9624200-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-2639718-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8501745-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8927546-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2007221021-B2 |
| priorityDate | 1973-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.