http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1446781-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5c24684033fba97d1ad845ce453a57e3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C51-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-235 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-732 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C59-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-16 |
| filingDate | 1973-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1976-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1446781-A |
| titleOfInvention | Pharmaceutical preparations comprising derivatives of phenyl propionic acid |
| abstract | 1446781 4-Hydroxy-3,5-dialkyl phenyl propionic acid and derivatives thereof HOECHST AG 20 Aug 1973 [18 Aug 1972] 39286/73 Heading C2C [Also in Division A5] Phenyl propionic acid derivatives of the formulae wherein R 1 and R 2 represent C 1-8 alkyl radicals, R 3 is a C 2-12 saturated hydrocarbon radical having n free bonds, X is OH, C 1-18 alkoxy, phenalkoxy with 1 to 4 carbon atoms in the alkyl group, C 5-8 cycloalkoxy or a group -NR 4 R 5 where R 4 is C 1-18 alkyl or benzyl and R 5 is H or R 4 and R 5 together with the nitrogen atom form a 6-membered heterocyclic ring which may contain an oxygen atom as a further hetero atom and n is an integer from 2 to 4, have hypolipaemic and hypoglycaemic activity and may be employed as ingredients of pharmaceutical compositions (see Division A5). In the examples of the preparation of the phenyl propionic acid derivatives, acrylonitrile is reacted with 2,6-di-tert.-butyl phenol in the presence of potassium and dry tert. butanol to yield 4- hydroxy - 3,5 - di. - tert. - butyl - phenyl propionitrile and this is hydrolysed to the 4-hydroxy- 3,5-di-tert.-butyl-phenyl propionic acid. From the acid there are prepared the methyl, n-butyl, octadecyl, benzyl, cyclohexyl, phenylethyl and pentaerythrityl esters, the ethylene glycol diester and the butylamide, benzylamide and morpholide. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0404039-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5552439-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5280046-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5281623-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5393786-A |
| priorityDate | 1972-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.