http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1440602-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05a203d85ee01909eaf728dc16f0f6cb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-935 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C405-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C405-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J23-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-935 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C401-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
| filingDate | 1973-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1976-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1440602-A |
| titleOfInvention | Cyclopentane derivatives |
| abstract | 1440602 Cyclopenta[b]furans PFIZER Inc 30 May 1973 [2 June 1972 30 April 1973] 23065/75 Divided out of 1440601 Heading C2C The invention comprises cyclopenta[b]furans of the formulµ wherein n is 0, 1 or 2; m is 0, 1, 2, 3 or 4; R 1 <SP>1</SP> is -COR 2 , wherein R 2 is C 1-5 alkyl, phenyl or p-biphenylyl; R is H or C 1-3 alkyl; R 1 is H, 2- tetrahydropyranyl or COR 2 ; and R 3 is H or 2-tetrahydropyranyl, with the proviso that when R 3 is 2-tetrahydropyranyl, R 1 is also 2- tetrahydropyranyl, and their preparation. The cyclopenta[b]furan-2-ols of Formula III above are prepared by reducing the corresponding cyclopenta[b]furan-2-ones of Formula II in which R 1 and R 3 are 2-tetrahydropyranyl, obtained by etherifying the corresponding compounds of Formula II in which R 1 and R 3 are both hydrogen, which are made by hydrolysing the corresponding cyclopenta[b]furan-2-ones of Formula II in which R 3 is 11 and R 1 is -COR 2 , the latter being obtained by either reducing the diketones of Formula I with sodium borohydride and separating the desired α-hydroxy isomers or by reacting the diketones of Formula I with C 1-3 alkyl lithiums and separating the desired α-hydroxy isomers. Diketones of Formula I are prepared by reacting phosphonates of the formula (CH 3 O) 2 PO.CH 2 .CO.(CH 2 ) 2 (CH 2 ) n O(CH 2 )mCH 3 with the appropriate 5α-acyloxy-3,3a#,4,5,6,- 6α# - hexahydro - 2 - oxo - 2H - cyclopenta[b]- furan - 4# - carboxaldehydes. Cyclopenta[b]- furan-2-ones of Formula IV above are obtained by hydrogenating the corresponding cyclopenta[b]furan-2-ones of Formula II in which R 1 and R 3 are both 2-tetrahydropyranyl. |
| priorityDate | 1972-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 37.