http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1438833-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_84d9adaa7e7ce01ce8020f5c721aba10 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C37-055 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C37-055 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-18 |
| filingDate | 1973-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1976-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1438833-A |
| titleOfInvention | Process for making benzopyrans |
| abstract | 1438833 Benzopyrones and benzopyrans ABBOTT LABORATORIES 21 Sept 1973 [16 Oct 1972 8 June 1973] 44478/73 Heading C2C Benzopyrones of the Formula (II) in which X is -S-, -NH-, -N-benzyl or -CH 2 - and the ring C contains 5 or 6 nuclear atoms and may have an alkyl group of 1 to 8 carbon atoms on the nitrogen atom or on the methylene group or is a quinuclidine ring and R 2 is a C 1 -C 20 alkyl group, a C 3 -C 8 cycloalkyl group, or a (C 3 -C 8 cycloalkyl)-C 1 -C 8 alkyl group or is a group of the formula in which each of R 3 , R 4 and R 5 is independently chosen from H, halogen, CF 3 and C 1 -C 8 alkyl, and Y is straight or branched C 1 -C 10 alkylene, are obtained by reacting a resorcinol of the formula with a #-keto-ester of the formula in which Alk is an alkyl group, in the presence of methane sulphonic acid and phosphorus oxychoride. Benzopyrans having the Formula I in which X, ring C and R 2 are as defined above and each R 1 is a C 1 -C 8 alkyl group, are obtained by reacting a benzopyrone of Formula II, obtained as described above, with 2 mols of an C 1 -C 8 alkyl magnesium halide under Grignard conditions. The benzopyrans are useful therapeutic agents, with activity in central nervous system, cardiovascular and analgesic areas. Preparation of intermediates is described as follows: 3 - (4 - fluorophenyl)propyl bromide is reacted with 3,5-dimethoxyacetophenone to give 2 - (3,5 - dimethoxyphenyl) - 5 - (4 - fluorophenyl)pentane, which is hydrolysed to 2-(3,5- dihydroxyphenyl)-5-(4-fluorophenyl)pentane. |
| priorityDate | 1972-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.