http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1436173-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4922c2d8ef3b675ad38900b030b925c6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C275-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-138 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C239-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C275-24 |
| filingDate | 1973-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1976-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1436173-A |
| titleOfInvention | Amines and process for their preparation |
| abstract | 1436173 Mono ethers of dehydroxy amines HASSLE AB 4 July 1973 [6 July 1972] 31869/73 Heading C2C Novel compounds of Formula I wherein R<SP>1</SP> is a C 1 -C 4 alkyl or hydroxy-C 1 -C 4 alkyl group, R<SP>2</SP> is a carbamoylamino-C 1 -C 4 alkyl, mono- or di-C 1 -C 4 alkylcarbamoylamino-C 1 -C 4 alkyl, carbamoylamino-C 1 -C 4 alkoxy, mono- or di-C 1 -C 4 alkylcarbamoylamino - C 1 -C 4 alkoxy, carbamoyloxy - C 1 -C 4 alkyl, mono- or di-C 1 -C 4 alkylcarbamoyloxy- C 1 -C 4 alkyl, carbamoyloxy-C 1 -C 4 alkoxy or mono- or di-C 1 -C 4 alkylcarbamoyloxy-C 1 -C 4 alkoxy group and R<SP>3</SP> is a hydrogen or halogen atom or a C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, (C 1 -C 4 alkoxy)methyl, C 1 -C 4 alkoxy, C 2 -C 4 alkenyloxy, C 2 -C 4 alkynyloxy, C 1 -C 4 alkylthio, C 2 -C 4 alkenylthio, C 2 -C 4 alkynlthio or C 1 -C 4 acyl groups are prepared by one of the following methods (a) and amine R<SP>1</SP>NH 2 is reacted with a compound of formula wherein X<SP>1</SP> is OH and Z is reactive esterified OH or X<SP>1</SP> and Z form an epoxy group; (b) a compound R<SP>1</SP>Z is reacted with an amine of formula (c) a compound of formula is reacted with a compound of formula (V) reduction of a compound selected from formulµ (d) by hydrolysis of a derivative which has an arylsulphonyl, benzoyl, cyano, silyl alkylidene benzylidene, phosphorylidene or substituted methylene substituent at the nitrogen atom of the amino group and/or at the hydroxy group, or reducing such a derivative having an arylsulphonyl substituent at the nitrogen atom or hydroxy group; (e) hydrogenation of a compound of formula or (f) by converting a group X<SP>2</SP> in a compound of Formula XI wherein X<SP>2</SP> is a hydroxyalkyl-, esterified hydroxyalkyl-, hydroxyalkoxy-, esterified hydroxyalkoxy-, hydroxy-, aminoalkyl-, aminoalkoxy-, alkanoylaminoalkyl-, alkanoylaminoalkoxy-, alkanoyloxyalkyl-, alkanoyloxyalkoxy-, aminothiocarbamylaminoalkyl-, aminothiocarbamylaminoalkoxy-, alkylaminothiocarbamylaminoalkyl-, alkylaminothiocarbamylaminoalkoxy-, imino(halo)carbaminoalkyl-, imino(halo)carbaminoalkoxy-, iminocarbiminoalkyl-, or iminocarbiminoalkoxygroup into a group as defined for R<SP>2</SP> in claim 1, using a method known per se for effecting such a conversion. Pharmaceutical compositions in conventional forms for oral, rectal or parenteral and having #-blocking activity comprise an above novel compound and a carrier or diluent. |
| priorityDate | 1972-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 35.