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filingDate 1974-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1976-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber GB-1434147-A
titleOfInvention Tripeptides
abstract 1434147 Tripeptides TAKEDA YAKUHIN KOGYO KK 12 Feb 1974 [23 Feb 1973] 06238/74 Heading C3H [Also in Division C2] Novel tripeptides of the formula where R 1 , R 2 , R 3 are hydrogen or an alkyl group of 1-3 carbon atoms and X is oxygen or sulphur, or a pharmaceutically acceptable acid salt thereof, are claimed. The compounds are prepared and isolated by a wide variety of conventional methods. The examples describe the preparation of L - 2 - oxo - oxazolidine - 4 - carbonyl - L- histidyl - L - prolineamide; L - trans - 5- methyl - 2 - oxo - oxazolidine - 4 - carbonyl - L- histidyl - L - prolineamide; L - 2 - oxothiazolidine - 4 - carbonyl - L - histidyl - L - prolineamide. The dipeptide, L-histidyl-L-prolineamide dihydrochloride is isolated. The tripeptides exhibit thyrotropin-releasing hormone action and are compounded with conventional pharmaceutically-inactive carriers and diluents to form tablets, capsules, granules or injectable solutions.
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Total number of triples: 45.