http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1431385-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f07293d4b34d8372fb0775181fef9d23 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D489-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D489-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D489-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-485 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D489-12 |
| filingDate | 1973-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1976-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1431385-A |
| titleOfInvention | N-heteroarylmethyl-endoetheneonororipavines and thebaine deri vatives |
| abstract | 1431385 Endoetheno-nor-oripavines and thebaines BOEHRINGER INGELHEIM GmbH 20 June 1973 [21 June 1972] 29346/73 Heading C2C [Also in Division A5] Novel compounds of the Formula (I) wherein R 1 is H, CH 3 or CH 3 CO, R 2 and R 4 each is H or CH 3 ; R 3 is H, CH 3 , n-C 3 H 7 , phenylethyl or phenyl; Y is -O- or -S-; and Z is -CH=CH- or -CH 2 CH 2 -, and acid addition salts thereof, may be obtained (a) by reacting a compound of Formula (II) with a compound of Formula (III) wherein X is an atom or group removable as an anion (e.g. halogen, AlkSO 2 O- or AT-SO 2 O- or trialkylammonium); (b) by reacting compound (II) with a compound of Formula (IV) and formaldehyde; (c) by reacting a compound (II) with a compound of Formula (V) in the presence of formic acid; (d) by reduction of a compound of the Formula (VI) or of Formula (VIa) (e) by reacting a compound of the Formula (VII) or a similar compound containing R 3 instead of R 2 , with a Grignard of the formula R 2 MgX or R 3 MgX (wherein X is Cl, Br or I), (f) by reduction of a compound similar to VII containing R 1 O in the 3-position, (g) by reduction of a compound of formula (VIII) (wherein R<SP>1</SP> is alkyl, aralkyl or aryl) with a complex metal hydride, or with a metal alkyl, or (h) by conversion of a compound of Formula (IX) (wherein Sch represents an alkyl, aralkyl or ester group). |
| priorityDate | 1972-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.