http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1430932-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_232361c9031a709144573276863c462b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J7-00 |
| filingDate | 1972-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1976-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1430932-A |
| titleOfInvention | 21-fluoro-pregnanes |
| abstract | 1430932 21-Fluoro-pregnane compounds GLAXO LABORATORIES Ltd 4 May 1973 [5 May 1972] 21144/72 Heading C2U Novel steroids of the pregnane or 19-norpregnane series possess a 5α-hydrogen atom or a 4,5-double bond, a 3α-OH group, a 17α-hydrogen atom, a 20-oxo group and a 21-fluorine atom. They may also possess other substituents and/or double bonds, e.g. a 2#-ethoxy group and an 11- keto group. They are prepared by reacting corresponding steroids possessing a readily eliminatable substituent at the 21-position, e.g. an iodine atom, with a source of fluoride ions, or by stereospecific reduction of corresponding 5α-H- 3-keto steroids. Substituents and double bonds may be introduced into the starting materials or final products by known processes. A 2# - bromo - 3α - hydroxy - 21 - unsubstituted steroid may be converted to a #<SP>1</SP>-2-unsubstituted - 3α - hydroxy - 21 - bromo steroid by bromination in the 21-position followed, with or without keto protection, by dehydrobromination in the 1,2-position. 3α - Hydroxy - 21 - iodo - 5α - pregnane- 11,20 - dione is prepared from the corresponding 21-bromo compound and sodium iodide. 21- Fluoro - 5α - pregnane - 3,11,20 - trione is perpared by oxidizing 21-bromo-3α-hydroxy-5α pregnane - 11,20 - dione to 21 - bromo- 5α- pregnane - 3,11,20 - trione, converting this to the corresponding 21-iodo compound and reacting this with silver fluoride. 21-Bromo-2#- ethoxy - 3α - hydroxy - 5α - pregnane - 11,20- dione is prepared by bromination of 2#-ethoxy- 3α - hydroxy - 5α - pregnane - 11,20 - dione, in turn prepared by reacting 2α-3α-epoxy-5α- pregnane-11,20-dione with ethanol in the presence of conc. H 2 SO 4 . The novel steroids are stated to be anaesthetics and they may be made up into anaesthetic compositions with suitable carriers. Particularly preferred are aqueous solutions containing non-ionic surface active agents, for parenteral use. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5593983-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-681714-B2 |
| priorityDate | 1972-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.