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filingDate 1973-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1976-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber GB-1430838-A
titleOfInvention 7beta-amino-cepham-3-one-4-carboxylic acid compounds and process for their manufacture
abstract 1430838 7 - Amino - cepham- and -cephem- 3 - one - 4 - carboxylic acid derivatives CIBAGEIGY AG 27 June 1973 [29 June 1972 22 Dec 1972] 30536/73 Heading C2C Novel compounds (I), which can exist in the enol form (Ia) wherein R<SP>a</SP> 1 represents hydrogen or an amino protective group R<SP>A</SP> 1 and R<SP>b</SP> 1 represents hydrogen or an acyl group Ac, or R<SP>a</SP> 1 and R<SP>b</SP> 1 together represent a bivalent amino protective group and R<SP>A</SP> 2 represents a radical which together with the carbonyl grouping -C(=O)- forms a protected carboxyl group, or 3-ketal derivatives, as well as 1-oxides, of compounds of the Formula I, or salts of such compounds, are made from compounds (II) (prepared from the corresponding -CH 2 OH compounds) or 1-oxides thereof, or are made by treating compounds (III) with a peracid to give corresponding formyloxy compounds or 1-oxides thereof and subsequently splitting the formyloxy group to give (I). The free acids corresponding to (I) and (Ia) (i.e. 4- carboxy compounds) are also prepared as well as the 3-acylates and 3-ethers of compounds (Ia).
priorityDate 1972-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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