http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1428186-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_39ae96c0ecc22ff90ff986371a3cea0f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D311-24 |
| filingDate | 1973-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1976-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1428186-A |
| titleOfInvention | Chromone derivatives |
| abstract | 1428186 Chromone derivatives FUJISAWA PHARMACEUTICAL CO Ltd 18 June 1973 [21 June 1972 24 June 1972 29 June 1972] 28883/73 Heading C2C Novel compounds of the Formula (I) wherein R<SP>1</SP> is an alkoxy radical, an N,S- containing heterocyclic radical (optionally substituted with halogen atoms or acyl radicals), or an aryloxy radical which may be substituted by amino, alkylamino, acylamino, nitro or alkylenedioxy radicals; R<SP>2</SP> is an alkylene radical; R<SP>3</SP> is a hydroxy group or an alkoxy radical or a group of the general formula -N(R 4 )R 5 , in which R 4 is a hydrogen atom and R 5 is -OH or -NH 2 , or -N(R 4 )R 5 denotes a piperazinyl radical substituted with an alkyl or hydroxyalkyl radical; provided that when R<SP>3</SP> is a hydroxy or alkoxy group, R<SP>1</SP> is an N,S- containing heterocyclic radical substituted by halo or acyl, or an aryloxy group substituted by amino, alkylamino, acylamino, nitro or alkylenedioxy; and the non-toxic, pharmaceuticallyacceptable salts thereof, may be obtained by reacting a compound of the Formula (II) with an oxalic acid derivative, followed by reaction with an acid, after which the product obtained (R 3 = alkoxy) may be hydrolysed to the free acid (R 3 = OH), which, if desired, is reacted with a compound of the formula HN(R<SP>4</SP>)R<SP>5</SP>. Salts are formed by conventional methods. An intermediate, sodium 2-ethoxalylacetyl- 3 - [2 - (3 - dimethylaminophenoxy)- ethoxy]- phenolate is obtained by reacting 2-[2-(3-dimethylaminophenoxy) - ethoxy] - 6 - hydroxyacetophenone with diethyl oxalate. Pharmaceutical compositions, having antiallergic activity, comprise at least one compound of Formula I, in admixture with a solid or liquid pharmaceutical diluent or carrier in forms suitable for enteral or parenteral administration. |
| priorityDate | 1972-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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