http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1428110-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7fa68ae66fed2f54717da32e57f7735f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D335-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D337-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D335-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D337-08 |
| filingDate | 1972-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1976-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1428110-A |
| titleOfInvention | Pharmaceutical antihypertensive and vasodilator compositions |
| abstract | 1428110 Benzothiepins; benzothiopyrans RECKITT & COLMAN PRODUCTS Ltd 17 May 1973 [30 May 1972] 25132/72 Heading C2C [Also in Division A5] Compounds of the general formula wherein n is 1, 2 or 3; p is 0, 1 or 2 and Y is -CH 2 -, -CHOH- or are prepared from dimethoxy thiophenols by the following reactions: (a) when Y is carbonyl and p is zero by reaction with an #-chloroalkanoic acid or a lactone in the presence of sodium ethoxide to form a dimethoxyphenylthioalkanoic acid which may be cyclized by heating in the presence of polyphosphoric acid; (b) when Y is methylene and p is zero by a Clemmenson reduction of a compound from reaction (a); (c) when Y is hydroxy methylene by reduction of a compound from (a) with LiAlH 4 . Compounds in which p is 1 may be obtained from those in which p is zero by oxidation using H 2 O 2 and acetic acid, N-bromo- or N-chloro-succinimide in methanol or 1-chlorobenzotriazole in methanol or CH 2 Cl 2 . preferably using an equimolecular amount of oxidizing agent. Compounds in which p is 2 may be obtained from those in which p = 0 by oxidation using excess H 2 O 2 in acetic acid at elevated (steam bath) temperatures. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7019023-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10512657-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-3632824-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5994391-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11229661-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6262277-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6107494-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11376251-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2587702-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6642269-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2587703-A1 |
| priorityDate | 1972-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.