http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1422304-A

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filingDate 1974-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1976-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber GB-1422304-A
titleOfInvention Penicillins processes for their preparation and their use as medicaments
abstract 1422304 Penicillin derivatives BAYER AG 18 April 1974 [19 April 1973 8 Sept 1973] 17020/74 Heading C2C Novel compounds I (in which R 1 is H, 1-5C alkyl, up to 8C aralkyl, aryl, substituted aryl or thienyl; A is a group of general formula (in which R 2 -R 7 are as R 1 and may be the same or different); B is a group of formula (in which R 8 -R 10 are H, F, Cl, Br, I, 1-6C alkyl, alkoxy, alkylthio or alkylsulphonyl, NO 2 , sulphamyl, CN, di(1-6C alkyl)amino, 1-6C alkanoylamino, 1-6C alkanoyloxy, 1-6C alkylsulphonamido, CF 3 or OH) ; E is O or S; and C* is a carbon atom constituting a centre of chirality) are prepared by reaction of a compound II (in which R 11 -R 13 are all H or R 11 -R 12 is -C(R 14 ) 2 - and R 13 is H or R 11 -R 12 are H and R 13 is trialkylsilyl or R 11 and R 13 are trialkylsilyl and R 12 is H and R 14 is 1-6C alkyl) with a compound III (in which W is halo, azido or a group of formula Compounds III may be prepared by reaction of compounds IV with a compound W-CE-W. Compounds IV may be prepared by reaction of hydrazine with an appropriately substituted acetic acid ester. Pharmaceutical compositions comprise a compound I together with suitable diluents or carriers and are useful as antibiotics and growthpromoters.
priorityDate 1973-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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Incoming Links

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Total number of triples: 29.