http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1416421-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9433d383d1922b3df0ca6c182c7d3925 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-472 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-24 |
| filingDate | 1974-01-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1975-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1416421-A |
| titleOfInvention | 1,4-dihydro-3 2h- isoquinolinone derivatives and preparation thereof |
| abstract | 1416421 1,4 - Dihydro - 1 - (4 - acylaminophenyl)-3(2H)isoquinolines EGYT GYOGYSZERVEGYESZETI GYAR 28 Jan 1974 [12 Feb 1973 13 Nov 1973] 03801/74 Heading C2C Novel compounds of the Formula I wherein R 1 and R 2 independently are hydrogen or C 1-3 alkyl, R is hydrogen or C 1-4 alkyl, R 3 is hydrogen, C 1-4 alkyl or benzyl or R and R 3 together with the adjacent nitrogen atom form a pyrrolidino, piperidino or morpholino group and m is zero (in which case R and R 3 may not both be hydrogen or 1 to 3 and pharmaceutically acceptable acid addition salts thereof may be prepared by reacting a compound of the Formula II with a compound A<SP>1</SP>-(CH 2 ) m COR 4 wherein when m is 1 to 3, R 4 is halogen or ethoxycarbonyloxy and A<SP>1</SP> is halogen or benzyloxycarbonylamino or when m is zero R 4 is ethoxy and A is halogen to form a compound IV which compound when A<SP>1</SP> is ethoxy or halogen is reacted with an amine RR 3 NH in which R and R<SP>3</SP> may not both be hydrogen or when A<SP>1</SP> is benzyloxycarbonylamino is subjected to catalytic hydrogenation followed optionally by salt formation. Pharmaceutical compositions of the compounds I with the usual excipients show anti-convulsive activity when administered orally or parenterally. |
| priorityDate | 1973-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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