http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1413133-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5635744f3e22ca8d710dd1f2707bee23 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-492 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N27-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-49 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N27-27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N27-401 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N27-416 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N27-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B5-145 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B5-1473 |
| filingDate | 1972-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1975-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1413133-A |
| titleOfInvention | Method and apparatus for electrochemical analysis of small samples of blood |
| abstract | 1413133 Electro-chemical analysis CORNING GLASS WORKS 20 Oct 1972 [21 Oct 1971] 48398/72 Heading G1N An electrode system of a pH flow through electrode, a pH reference electrode, a pCO 2 electrode and a PO 2 electrode enable pH, base excess, HCO #3 , total CO 2 , PCO 2 and PO 2 of a sample of blood to be obtained. The electrodes are mounted in an overall measuring chamber in a stainless steel housing 32 the chamber being made up of parts 3-3a-3a'-3b. A blood sample is introduced into the port 1 either by a syringe or a capillary in which case the blood is drawn into the measuring chamber by means of a peristallic pump Fig. 1 (not shown) until it fills the whole chamber as viewed through viewer 47 positioned over the exit 10 of part 3b. After the measurements have been made the sample is withdrawn and the chamber flushed by fluid entering at 23. The chamber is maintained at a constant temperature by heating aluminium transfer blocks 31 by heating elements 33 the temperature being sensed by thermistor 49. In addition a further thermistor 49a measures the temperature of the sample and its output is used to control its temperature. pH measuring electrode assembly 4 is mounted in the housing 32 and is of the flow-through type of a vanadium clad pH sensor glass capillary tube 5 with a solid fused crystalline layer of silver halides through which is coiled a silver wire. The silver wire is connected with contact 27 to provide an output. pH reference electrode assembly 35 includes a semi-permeable membrane 37 in contact with the sample in capillary 3a and a sodium chloride electrolyte bridge, the area of the electrolyte in contact with the membrane being less than the area of the membrane in contact with the sample to form a wick. PCO 2 electrode Capillary tube 3a' interconnects the tube 3a with a cylindrical chamber 3b coated with plastics material. One of the ends of the chamber 3b is closed by the membrane of the PCO 2 electrode. The membrane is spaced from a pH sensitive glass electrode by a fibre spacer and the space filled with a buffered bicarbonate electrolyte. PO 2 electrode The semi-permeable membrane of the electrode closes the other end of the chamber 3b and also an outer tube constituting an electrolyte reservoir. Within the tube are two concentric half cells consisting of a Ag/Ag Cl anode and a platinum cathode. Circuitry Fig. 1 (not shown). The outputs of the pH and pH reference electrodes are applied to a differential amplifier the output of which expresses pH on a digital meter. Similarly the outputs of the PCO 2 and PO 2 electrodes are expressed on respective digital meters. In addition an analogue calculator is provided to give HCO #3 from the outputs of the pH and PCO 2 electrodes. The total CO 2 is obtained from a further calculator to which is applied the HCO 3 value and the output of the PCO 2 electrode. Base excess is also calculated from the values of HCO 3 and pH. |
| priorityDate | 1971-10-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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