http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1410854-A

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filingDate 1973-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1975-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber GB-1410854-A
titleOfInvention Pharmaceutically useful prostaglandin derivatives
abstract 1410854 Prostaglandins SANKYO CO Ltd 24 Aug 1973 [1 Sept 1972] 40176/73 Heading C2C Novel compounds of Formula I in which A=C 4-8 alkylene, R<SP>1</SP> = C 4-10 alkyl, R<SP>2</SP>=H or C 1-6 alkyl and R<SP>3</SP>=H or C 1-6 alkoxycarbonyl, and pharmaceutically acceptable salts thereof, are prepared by reducing a compound of Formula II in which Z=a protected carbonyl group, with a metal hydride complex reducing agent, to give a compound of Formula III removing the protecting group from the compound of Formula III and, if appropriate, salifying the product obtained. Compounds I in which R<SP>2</SP> and R<SP>3</SP> are both H can also be prepared by hydrolysis of a compound I in which R<SP>2</SP>= alkyl and/or R<SP>3</SP>=alkoxycarbonyl. The corresponding groups can also be removed from compounds III, to give compounds in which R<SP>2</SP>=R<SP>3</SP>=H. Starting materials of Formula II and intermediates therefor are prepared as shown in the following reaction scheme Pharmaceutical compositions having oxytocic activity, for parenteral administration, comprise a compound I, or a pharmaceutically acceptable salt thereof, and a pharmaceutical carrier or diluent.
priorityDate 1972-09-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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Total number of triples: 25.