http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1391288-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5c24684033fba97d1ad845ce453a57e3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-645 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-5304 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D243-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-645 |
| filingDate | 1972-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e2ff416d7b5234de801fb82168f8d5d5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9790cb15c644a1d0061d73cf2e55f4ac |
| publicationDate | 1975-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1391288-A |
| titleOfInvention | Phosphorus-containing derivatives of benzo-1,5-diazepines |
| abstract | 1391288 Phosphorus-containing derivatives of benzo-1,5-diazepines HOECHST AG 13 April 1972 [15 April 1971] 17101/72 Heading C2P The invention comprises compounds of the general formula wherein R 1 and R 2 are selected from H, halogen, methoxy, ethoxy, N0 2 and CF 3 , R 3 is H, methyl, ethyl, n-propyl or isopropyl, R 4 and R 5 are selected from methyl, ethyl, n-propyl and isopropyl and n is 1, 2 or 3. They are obtained either (a) by reacting with wherein X is halogen or an alkyl- or arylsulphonic acid radical, the reaction being carried out in the presence of a metallizing agent, e.g. an alkali metal hydride, amide or alcoholate, or an alkaline earth metal hydride, the starting material II being optionally formed in situ by alkaline cyclization of a corresponding N-(2- aminophenyl)-N-phenyl malonic acid alkyl ester amide and then reacted, without isolation, with the compound III; or (b) by reacting a compound with a malonic acid dihalide or an appropriately substituted malonic acid dihalide. The products are suitable in the treatment of psychic diseases and may be administered in conventional pharmaceutical forms. The compounds of Formula IV may be obtained by reacting a correspondingly substituted 1-phenyl benz[(d)]imidazole with a compound III and then cleaving the imidazole ring by means of an alkali, an example being given for the production of 5-chloro-2-(dimethylphosphinylmethyl)amino diphenylamine and its corresponding substituted benzimidazolyl chloride precursor. |
| priorityDate | 1971-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.