http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1388268-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c1cd6051bf69f25a0652ded4e4edac31 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C321-00 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D335-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D335-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 |
| filingDate | 1971-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1975-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1388268-A |
| titleOfInvention | Benzodithiapyrones |
| abstract | 1388268 Dioxobenzodithiapyran - dicarboxylic acids FISONS Ltd 25 May 1972 [24 June 1971] 29573/71 Heading C2C Novel dioxobenzodithiapyran - dicarboxylic acids of the general formula wherein an adjacent pair of P, Q, R and T forms a -CO-CH=C(COOH)-S- group and the remainder of P, Q, R and T each represent a hydrogen or halogen atom, an alkyl or alkoxy group optionally substituted by a hydroxy, alkoxy or aryl group or a halogen atom, an alkenyl, alkenyloxy, amino, mono- or di- C 1-6 alkylamino, nitro, hydroxy, acyl or aryloxy group or an aminoalkoxy group optionally substituted by a C 1-6 alkyl group, and pharmaceutically acceptable salts, esters and amides thereof are prepared by cyclizing a benzene-bisthiofumaric acid of the general formula wherein an adjacent pair of P<SP>1</SP>, Q<SP>1</SP>, R<SP>1</SP> and T<SP>1</SP> forms a -CO-CH=C(COOM)-S- group or represents a hydrogen atom and a group and the remainder of P<SP>1</SP>, Q<SP>1</SP>, R<SP>1</SP> and T<SP>1</SP> each have the same significance as the remainder of P, Q, R and T, and M is a hydrogen or alkali metal atom, followed optionally by conversion of a resulting acid to a salt thereof or of a resulting salt to the free acid or another salt, or by conversion of a resulting acid or salt to an ester or amide. Benzene - bis - thiofumaric acids of the second general formula above are prepared by reacting a thiophenol of the general formula wherein P<SP>2</SP>, Q<SP>2</SP>, R<SP>2</SP> and T<SP>2</SP> are as P<SP>1</SP>, Q<SP>1</SP>, R<SP>1</SP> and T<SP>1</SP> except that an adjacent pair of P<SP>2</SP>, Q<SP>2</SP>, R<SP>2</SP> and T<SP>2</SP> may represent a hydrogen atom and a -SM group, with acetylene-dicarboxylic acid or an ester or salt thereof under alkaline conditions, followed, if necessary, by hydrolysis. Pharmaceutical compositions, which inhibit the release and/or action of pharmacological mediators which result from the in vivo combination of certain types of antibody and specific antigen, comprise, as active ingredient, a dioxobenzodithiapyran-dicarboxylic acid of the first general formula above or a pharmaceutically acceptable salt, ester or amide thereof, in combination with a pharmaceutically acceptable adjuvant, diluent or carrier. |
| priorityDate | 1971-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.