http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1385811-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5e0f130ff5aa5601d47b71c83fa0d7e8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-20 |
| filingDate | 1972-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1975-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1385811-A |
| titleOfInvention | 1-amino pyrazole derivatives and pharmaceutical compositions containing them |
| abstract | 1385811 1-Amino pyrazole derivatives and pharmaceutical compositions containing them ETABS NATIVELLE SA 16 April 1973 [14 Jan 1972 (2)] 1864/72 and 1866/72 Heading C2C The invention comprises compounds of formula wherein X is R and R<SP>1</SP> cannot be present at the same time but each, if present, represents a hydrogen atom or a (C 1-4 ) alkyl group with the proviso that neither of R and R<SP>1</SP> is present when X is R<SP>2</SP> and R<SP>3</SP>, which may be the same or different each represents a hydrogen atom, a C 1-4 alkyl or phenyl group which phenyl group may be substituted by one or more C 1-4 alkyl groups, halogen atoms, -NO 2 groups or C 1-4 alkoxy groups, or R<SP>1</SP> and R<SP>2</SP> together represent a benzylidene group; R<SP>4</SP> represents an amino group that is unsubstituted or substituted by one or more C 1-4 alkyl groups or a benzylidineamino group; and R<SP>5</SP> represents a hydrogen atom or a C 1-4 alkyl group. These compounds may be prepared by a process which comprises the steps:-(a) effecting an internal rearrangement of a 5-hydrazinoisoxazole of formula in which R<SP>2</SP> and R<SP>3</SP> are as above defined, in the presence of hydrazine to obtain a compound of formula in which R<SP>5</SP> is H, and R<SP>4</SP> is -NH 2 , in admixture with its keto isomers; (b) if desired alkylating the 5-hydroxy group of the enol isomer and/or the ring nitrogen atom of the 2-position of the keto isomer of the product by treatment with an alkylating agent; (c) if desired mono- or dialkylating the 1-amino group of the product of step (a) or step (b) by treatment with one or two alkylating agents; (d) if desired introducing a benzylidene substituent at the 1-amino group by reacting the product of step (a) or step (b) with benzaldehyde and (e) if desired introducing a benzylidene substituent at the 4-position of a 2,4-unsubstituted-2,3-unsaturated keto component of the product of step (a), (c) or (d) with benzaldehyde. The resulting compounds may, if desired, be converted to their acid addition salts. The invention also comprises a pharmaceutical composition which contains as an active ingredient a compound according to the invention. |
| priorityDate | 1972-01-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 24.