http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1383220-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c902faf6ae746c51fc8010672fc22894 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-227 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23K20-116 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C241-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-227 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23K1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D521-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-86 |
| filingDate | 1972-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1975-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1383220-A |
| titleOfInvention | Triazole derivatives and the manufacture thereof |
| abstract | 1383220 3 - Aminomethyl - 4 - (o - benzyl- and benzoyl - phenyl) - 4H - 1,2,4 - triazoles UPJOHN CO 18 July 1972 [18 Aug 1971] 33589/72 Heading C2C 3 - Aminomethyl - 4 - (o - benzoylphenyl)- 4H-1,2,4-triazoles and novel 3-aminomethyl-4- (o-benzylphenyl)-4H-1,2,4-triazoles of the respective general formulae wherein R 1 is a hydrogen atom or a C 1-3 alkyl, C 3-8 cycloalkyl, phenyl, benzyl or -COOR<SP>1</SP> group (R<SP>1</SP> is a C 1-3 alkyl group) or a heterocyclic aromatic group of 5 or 6 ring atoms, 1-4 of which are selected from O, N and S, each of R<SP>11</SP> and R<SP>111</SP> is a C 1-3 alkyl group or R<SP>11</SP> R<SP>111</SP>N is a pyrrolidino, piperidino or morpholino group, and each of R 2 , R 3 , R 4 and R 5 is a hydrogen or halogen atom or a C 1-3 alkyl, nitro, cyano, trifluoromethyl, C 1-3 alkoxy, C 1-3 alkylthio, C 1-3 alkylsulphinyl, C 1-3 alkylsulphonyl, amino, C 1-3 alkanoylamino or di-C 1-3 alkylamine group, and pharmacologically acceptable acid addition salts thereof are prepared by heating in an organic solvent a 4-(o-benzoylphenyl)-4H-1,2,4-triazole or 4 - (o - benzylphenyl) - 4H - 1,2,4 - triazole of the respective general formulae with formaldehyde, paraformaldehyde and water or formalin and either hydrochloric acid and an amine of the general formula R<SP>11</SP> R<SP>111</SP>NH or the hydrochloride of the said amine, followed optionally by salification of the product. The 3 - aminomethyl - 4 - (o - benzoylphenyl)- 4H-1,2,4-triazoles may also be obtained by oxidizing the 3 - aminomethyl - 4 - (o - benzylphenyl) - 4H - 1,2,4 - triazoles with Jones' reagent. 4 - (o - Benzoylphenyl) - 4H - 1,2,4 - triazoles of the third general formula above are prepared (a) by treatment of the corresponding triazole-3- carboxaldehyde methanol solvate with silver oxide in aqueous methanol and (b) by treatment of an appropriate 2-chloro-4-phenyl-quinoline with hydrazine hydrate, reaction of the resulting 2 - hydrazino - 4 - phenylquinoline with an appropriate triethyl ortho-carboxylate and oxidation of the resulting 5-phenyl-s-triazolo- [4,3-a]-quinoline at a low temperature with sodium periodate and ruthenium dioxide. 2<SP>1</SP>-Benzoyl-4<SP>1</SP>-chloroacetanilide is prepared by reaction of 2-amino-5-chlorobenzophenone with acetyl chloride. Pharmaceutical compositions having sedative, tranquillizing, hypnotic, muscle-relaxant and anticonvulsant activity comprise, as active ingredient, a 3-aminomethyl-4-(o-benzylphenyl)- 4H-1,2,4-triazole of the second general formula above or a pharmacologically acceptable acid addition salt thereof, together with a pharmaceutically acceptable carrier. |
| priorityDate | 1971-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 81.