http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1382840-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_76195fd1cd08192222699d8e7a88c231 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-20 |
| filingDate | 1971-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1975-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1382840-A |
| titleOfInvention | Heterocyclic ureidocephalosporins |
| abstract | 1382840 Ureidocephalosporins E R SQUIBB & SONS Inc 22 Nov 1971 [27 Nov 1970] 54161/71 Heading C2C New ureidocephalosporins having the general Formula (I) and salts, C 1-7 , alkyl esters and acyloxymethyl esters thereof, wherein R is a furyl, pyridyl, pyrryl or thienyl radical which may be substituted by halogen, nitro, C 1-4 alkylsulphonyl or arylsulphonyl, n is 0, 1 or 2, and Z is a radical left by removal of a hydrogen from the 7-amino group of 7-aminocephalosporanic acid (7-ACA) or 7-aminodesacetoxycephalosporanic acid (7- ADCA), are prepared (i) by reacting an amino acid of Formula (II) or an N-protected acylating derivative thereof, with 7-ACA or 7-ADCA followed by reaction of the product with alkali metal cyanate or alkaline earth metal cyanate in the presence of water or (ii) by reacting an acid anhydride of Formula (III) wherein R<SP>1</SP> is C 1-5 alkyl, phenyl or phenyl C 1-5 alkyl, with 7-ACA or 7-ACDA; and if required, subsequently esterifying the product. Furfural is reacted with ammonium cyanide and the resulting amino nitrile is hydrolysed to give furyl-2-(2-amino)-acetic acid, which is reacted with potassium cyanate and water to give furyl-2-(2-ureido)-acetic acid. The compounds (I) have antibiotic activity, and are mixed with a pharmaceutically acceptable carrier to provide antibacterially active pharmaceutical compositions. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2164339-A |
| priorityDate | 1970-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 35.