http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1382345-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_76195fd1cd08192222699d8e7a88c231 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-04 |
| filingDate | 1972-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1975-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1382345-A |
| titleOfInvention | Thiazolo 3,4-alpha benzimidazole derivatives and process |
| abstract | 1382345 Thiazolo-[3,4-a]-benzimidazole derivatives E R SQUIBB & SONS Inc 18 Jan 1972 [21 Jan 1971] 2376/72 Heading C2C Novel compounds of the Formulae I and II wherein R<SP>1</SP> is halogen, hydroxy, nitro, alkyl, aryl, aryl-alkyl, alkoxy, cyano, thiocyano, arylamino, alkylamino, or R 2 CONH-; R<SP>2</SP> is hydrogen, C 1-5 alkyl, halo-C 1-5 alkyl, aryl, aryl alkyl; R<SP>3</SP> is any of R<SP>2</SP>, alkylamino, arylamino, aryl-alkylamino, or R<SP>2</SP> CONH-, R<SP>4</SP> is any of R<SP>2</SP>, alkoxy or aryloxy; R<SP>5</SP> is any of R<SP>2</SP>, alkylamino, arylamino, aryl-alkylamino, acylamino (NHCOR<SP>2</SP>), alkoxy or aryloxy;, n is 0, 1 or 2# and pharmaceutically acceptable salts thereof may be prepared by (a) for I, by reaction of a compound III with an acid halide R<SP>2</SP>COX where X is chlorine or bromine, an acid anhydride (R<SP>2</SP>CO) 2 X or an isocyanate R<SP>6</SP>NCO where R<SP>6</SP> is C 1-5 -alkyl, aryl, acyl (R<SP>2</SP>CO) or aryl-C 1-7 alkyl; (b) for II in which R<SP>4</SP> and R<SP>5</SP> are identical by acylation of a compound III with R<SP>2</SP>COX or (R<SP>2</SP>CO) 2 O or reaction of III with a halocarbonic acid R<SP>5</SP>COX where R<SP>5</SP> is alkoxy or aryloxy and X is as above or (c) for II in which R 4 and R 5 are different, reacting a compound I where in R<SP>3</SP> is alkylamino, arylamino, or aryl alkylamino or acylamino (R 2 CONH) with an acylating agent R<SP>4</SP>COX or (R<SP>4</SP>CO) 2 O where R<SP>4</SP> is as R<SP>2</SP> above or reacting a compound I in which R<SP>3</SP> is acylamino with a halocarbonic acid R<SP>5</SP>COX as in (b). 1 - Imino - 1H,3H - thiazolo - [3, 4 - a] - benzimidazole may be prepared by reaction of 2- chloromethyl-benzimidazole with ammonium thiocyanate. Pharmaceutical compositions of the compounds I and II show parasiticide and antiinflammatory activity when administered orally or topically. The compounds are also rodenticides. |
| priorityDate | 1971-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.