http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1375170-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C61-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C61-39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D317-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-757 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C49-697 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C45-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C49-697 |
| filingDate | 1971-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1974-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1375170-A |
| abstract | 1375170 Indonecarboxylic acid derivatives TAKEDA YAKUHIN KOGYO KK 23 Dec 1971 [29 Dec 1970 6 May 1971] 60022/71 Heading C2C The invention comprises compounds of formula and their alkyl esters, amides and metal salts, wherein R<SP>1</SP> is H or halogen, and a process for making them by reducing the corresponding oxocyclohexyl analogues (A), optionally followed (where R<SP>1</SP> = H in the product) by halogenation. Other exemplified methods of preparation are:- making an amide from the methyl ester, with NH 3 ; esterifying the acid with CH 2 N 2 ; hydrolysing methyl esters; salt formation; separation of stereoisomers; and perfusion through mamalian liver, of an (unsubstituted-cyclohexyl) analogue. Intermediates otherwise prepared are the ethyleneketals and a semicarbazone of cyclohexanones (A); the following ketones and their ethyleneketals:-4-(oxocyclohexyl)benzyl chlorides and cyanides, 4-(oxocyclohexyl)phenylsuccinic acids; 4-(oxocyclohexyl)phenylsuccinic anhydrides; the alpha-cyano derivatives of 4- (oxocyclohexyl)phenylacetic and -succinic acids, ethyl esters, ethyleneketals; methyl 5-(4- oxocyclohexyl)indane- 1 - carboxylate, ethyleneketal; and 5-(oxocyclohexyl)-3-oxoindane- 1-carboxylic acids. Therapeutic compositions for oral, parenteral or rectal administration comprise the above acids, esters, salts and amides, which have antiinflammatory, analgesic, antipyretic and antirheumatic activity. |
| priorityDate | 1970-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.