http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1374329-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ca2e4410855da087e11bf3eea8933fa |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-122 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-062 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-12 |
| filingDate | 1972-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1974-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1374329-A |
| titleOfInvention | Polypeptides and processes for their preparation |
| abstract | 1374329 Peptide and amino acid derivatives ELI LILLY & CO 17 Nov 1972 [19 Nov 1971] 53130/72 Heading C2C Novel compounds I in which R 1 is C 1 -C 5 alkyl, C 5 -C 7 cycloalkyl, benzyl, C 1 -C 5 alkoxybenzyl, p-nitrobenzyl, or 2,2,2-trihaloethyl; R 2 and each R 4 independently are hydrogen or C 1 -C 5 alkyl; R 3 and each R 5 independently are hydrogen, C 1 -C 5 alkyl, hydroxy-substituted C 1 -C 5 alkyl, protected hydroxy-substituted C 1 -C 5 alkyl, aminosubstituted C 1 -C 5 alkyl, protected aminosubstituted C 1 -C 5 alkyl, mercapto-substituted C 1 -C 5 alkyl, protected mercapto-substituted C 1 -C 5 alkyl, C 1 -C 5 alkyl mercapto-substituted C 1 -C 5 alkyl, guanidino-substituted C 1 -C 5 alkyl, protected guanidino-substituted C 1 -C 5 alkyl, imidazolylmethyl, protected imidazolylmethyl, indolylmethyl, phenyl, 4-hydroxyphenyl, protected 4-hydroxyphenyl, carbamyl-substituted C 1 -C 5 alkyl, or carboxysubstituted C 1 -C 5 alkyl protected by any of the R 1 substituents, at least one R 3 or R 5 being a protected carboxy-substituted C 1 -C 5 alkyl and at least one but not all of the protected carboxy substituents in said compound being protected by p-nitrobenzyl or CR 2 CX 3 (X is halogen); R 6 is hydrogen or an amino-protecting group; and p is 0 or an integer of 1 to 14 are prepared by methods well known in the peptide art. The p-nitrobenzyl and CH 2 CX 3 groups may be selectively cleaved, while avoiding cleavage of all other protected carboxy substituents by use of zinc and dilute acid. Intermediates isolated are CBO-asp(Bz)- OH and BOC-glu(Bz)-OH. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-4161522-A |
| priorityDate | 1971-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.