http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1367163-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_73ee0bacab5a7576a6a3244747f6ea99 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F5-025 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-02 |
| filingDate | 1972-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1974-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1367163-A |
| titleOfInvention | Boron compounds |
| abstract | 1367163 Organoboron compounds IMPERIAL CHEMICAL INDUSTRIES Ltd 8 Sept 1972 [4 Oct 1971 6 July 1972] 46047/71 and 31691/72 Heading C2B Compounds of the general formula where X is -O.CH=CH- which may be substituted on the carbon atom adjacent oxygen by halogen or C 1-8 alkyl, alkenyl, alkoxy, alkylthio or aralkyl, R<SP>1</SP> is C 1-6 alkyl, or aryl or aralkyl of up to C 10 which may bear 1-3 substituents selected from halogen, amino, nitro, or C 1-3 alkyl, alkoxy, alkylthio or alkanoylamino groups, or is a heterocyclic radical which may be substituted by halogen or C 1-3 alkyl, alkoxy or alkylthio, and R<SP>2</SP> and R<SP>3</SP> are each H, OH, C 1-4 alkoxy, C 1-10 alkyl, aryl of up to C 10 optionally substituted as above or a heterocyclic radical optionally substituted as above, or R<SP>3</SP> is an optionally substituted heterocyclicoxy radical, are prepared by the following processes: (1) for those compounds where R<SP>3</SP> is hydroxy or alkoxy; (a) by reaction of a compound of formula where one of R<SP>4</SP> and R<SP>5</SP> is a radical of formula -COR<SP>2</SP> and the other is B(R<SP>3</SP>) 2 and R<SP>6</SP> is H, halogen, or C 1-8 alkyl, alkenyl, alkoxy, alkylthio or aralkyl with a sulphonohydrazide R<SP>1</SP>SO 2 .NH.- NH 2 in the presence of an acid; or (b) by cyclization of a compound of formula where R<SP>6</SP> is as above, one of R<SP>7</SP> and R<SP>8</SP> is -CR<SP>2</SP> : N.NHSO 2 R<SP>1</SP> and the other is -B(R<SP>3</SP>) 2 , in the presence of an acid. (The compounds of Formula III are also claimed per se). (2) For compounds where R<SP>3</SP> is other than hydroxy, by reaction of a furodiazaborine of formula or an alkali metal salt thereof, where R<SP>9</SP> = R<SP>3</SP> other than hydroxy, with an acylating agent derived from a sulphonic acid R<SP>1</SP>SO 2 .OH; or (3) for compounds where R<SP>3</SP> is alkoxy or heterocyclic-oxy, by reaction of a furylboronic acid of formula with an alcohol or heterocyclic alcohol R<SP>3</SP>H. The compounds possess anti-bacterial and antifungal properties and may be incorporated in pharmaceutical or veterinary compositions in the form of tablets, capsules, sterile injectable solutions or suspensions, or ointments, creams or solutions for topical use. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/FR-2365573-A1 |
| priorityDate | 1971-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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