http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1347665-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4b18d70d8bf538fb533d0aa5cf87170d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P35-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P35-04 |
| filingDate | 1972-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1974-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1347665-A |
| titleOfInvention | Process for the production of cephalexin |
| abstract | 1347665 Preparation of cephalexin TOYO JOZO KK 18 Aug 1972 [20 Aug 1971 14 Jan 1972] 38587/72 Heading C2A Cephalexin (7 - (D - α - aminophenylacetamido) - desacetoxy cephalosporanic acid) is prepared by reacting 7-aminodesacetoxy-cephalosporanic acid with D-phenylglycine or a reactive derivative thereof such as D-phenylglycine methyl or ethyl ester, D-phenylglycine amide, and D-phenylglycyl-glycine, -leucine or -alanine, in an aqueous medium in the presence of acylating enzyme derived from a microorganism selected from the genera Alcaligenes, Achromobacter, Flavobacterium, Bacillus and Beneckea such as Alcaligenes faecalis ATCC 8750, Achromobacter Nov. Sp. B-402-2 NRRL B-5393, Flavobacterium aquatile NRRL B-5394, Bacillus megaterium NRRL B-5385, Beneckea hiperoptica ATCC 15803, Flavobacterium capsulatum ATCC 14666. The acylation may be carried out batchwise or in a column, at a temperature of 20-45‹ C., at a pH of 5À5-7À5, for 0À5 to 3 hours, with a 2-20 molar excess of the D-phenylglycine reaction component, referred to the 7-aminoacetocy-cephalosporanic acid. The acylating enzyme preparations may be in the form of culture broths, bacterial cells, treated bacterial cells, enzyme extracts, solid phase enzyme preparations or insoluble enzyme preparations of the micro-organisms. Insolubilized enzyme preparations comprise a culture broth of the micro-organism, microbial cells thereof or enzyme prepared therefrom, absorbed on a solid carrier such as diatomaceous earth, acid clay, active clay, alumina, kaolin, calcium phosphate, hydroxy apatite, CM - cellulose, DEAE-cellulose, TEAE-cellulose or carboxymethyl cross-linked dextran. |
| priorityDate | 1971-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.