http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1345340-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a717ea5b2ac78ac329ab3a9659d834d2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-0088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-0085 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-007 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-0096 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J1-0059 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J1-00 |
| filingDate | 1971-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1974-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1345340-A |
| titleOfInvention | 13-polycarbon-alkyl-16-methylgona-1,3,5-1o-trienes |
| abstract | 1345340 13 - Polycarbonalkyl - 16 - methylgona-1,3,5(10)-trienes AMERICAN HOME PRODUCTS CORP 23 Sept 1971 [23 Sept 1970] 21061/73 Divided out of 1345339 Heading C2U Novel steroids of the formula (wherein R 1 is C 1-6 alkyl or a C 3-7 cycloaliphatic radical, R 2 is C 2-18 alkyl and R 3 is C 1-6 alkyl or C 2-6 alkynyl) are prepared by reductive alkylation or alkynylation of steroids of the formula to give 16#-methyl-17α-alkyl-17#-ols or 16(α or #) - methyl - 17α - alkynyl - 17# - ols and, when required, hydrogenation of the latter to give 16(α or #) - methyl - 17α - alkyl - 17# - ols. In the alkynylation process epimerization of the 16-methyl substituent may occur, depending on the reagent used. Thus, use of MgBrC#CBrMg results in a 16#-methyl-17α-ethyryl-17#-ol as the major product while use of lithium acetylideethylenediamine complex results in a 16α- methyl-17α-ethynyl-17#-ol. Steroids of the second general formula above are prepared by catalytic hydrogenation of steroids of the formula which are in turn prepared by subjecting corresponding 16-unsubstituted steroids to a Mannich reaction to give steroids of the formula and treating these with a base. In examples illustrating the above processes, the starting materials, intermediates and products are in racemic form. The novel steroids are stated to possess hormonal activity as estrogens and/or antilipaemics. They may be made up into pharmaceutical compositions with suitable carriers. |
| priorityDate | 1970-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID453685600 http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID2724010 |
Total number of triples: 17.