http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1342761-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b3616f20274768727c431e0add3bdbde |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-44 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-44 |
| filingDate | 1971-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1974-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1342761-A |
| titleOfInvention | Preparation of a whole eye extract |
| abstract | 1342761 Whole eye extract "BIOFARM" FABRICA DE MEDICAMENTE 8 April 1971 9098/71 Heading ASB A whole eye extract is prepared from bovine eyes by removing adherent tissues from the eyeballs, washing the eyeballs with a dilute aqueous solution of alkali metal merthiolate, followed by autolysis of 0‹ to +4‹C., hashing the autolysed eyeballs, extracting the hash with alcohol, filtering the extract thus obtained, concentrating and drying the alcoholic extract, redissolving the dried extract in water and standardising the solution. Preferably the alcoholic extraction is carried out with 2 ml of rectified alcohol for every gram of eye hash, the extraction being performed first with mechanical agitation followed by a rest period of 24 hours. The alcoholic extract is filtered in a first stage in a press and then through a dense cloth, the filtration being repeated 4 or 5 times through filter paper. Concentration of he extract is performed under vacuum at a temperature not above 52‹C for the removal of alcohol and of part of the water to give a paste-like consistency, then by mixing the concentrate with 10% of purified diatomaceous earth and maintenance at 90‹-100‹C to complete dryness, finally removing the remaining water in a desiccator in the presence of solid absorbents. Following this, the dry extract, tested for the presence of albumin, is dissolved in water in several stages in the course of which the sediment is separated by centrifugation for the complete removal of diatomaceous earth and finally the extract is standardised such that one milli litre of the final extract is the equivalent of one gram of hash. The whole eye extract is employed in the ophthalmological therapy for the treatment of myopic chorio-retinitis, ocular astenopia, vitreous body opacities, iritis and iridocyclitis and corneal ulcerations and may be administered by sub-conjunctival and/or subcutaneous injection. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0671924-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0671924-A4 |
| priorityDate | 1971-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.