http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1341698-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b6506cf133be42545d51d1490056f6af |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D237-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-02 |
| filingDate | 1971-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1973-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1341698-A |
| titleOfInvention | 3-amino-indeno-1,2,3-a,e-phthalazines and pharmaceutical compositions thereof |
| abstract | 1341698 Indenophthalazines ASPRONICHOLAS Ltd 19 April 1971 [14 March 1970] 12424/70 Heading C2C The invention comprises compounds of formula and their acid addition and quaternary ammonium salts, wherein R 1 and R 2 are each H, OH, halogen, CN, NO 2 , NH 2 or C 1-6 alkyl or alkoxy, and R is (i) NR 3 R 4 (but not NH 2 ) where R 3 and R 4 are each H, alkyl, hydroxyalkyl, haloalkyl, substituted Ph, Ph-alkyl, substituted Ph-alkyl, C 3-8 cycloalkyl or (C 3-8 -cycloalkyl)- alkyl, or (ii) (NH-A) n -X, where A is C 1-4 alkylene or the unsaturated analogue, n is 0 or 1 and X is pyrrolidine, piperidine or hexamethyleneimine or their unsaturated analogues, or analogous rings where one C atom is replaced by O, N or S (when n is 0, X must be attached by its N atom to the indenophthalazine ring), or X is 4-substituted piperazino. The term "alkyl" in the foregoing includes the analogous alkenyl and alkynyl radicals. These compounds are prepared by reacting a corresponding 3-haloindenophthalazine (obtained from the indenophthalazone with POCl 3 ) with HR, or by standard interconversion procedures from compounds thus obtained. Also prepared is 3- chlorofluorenone-1-carboxylic acid. Therapeutic compositions for oral, parenteral or rectal administration comprise compounds of the above formula, which have anti-inflammatory (especially antirheumatic) activity, and in some cases immunosuppressive activity. |
| priorityDate | 1970-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.