http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1341109-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12cedce8d26d81271038993ba4912fe6 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D455-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D455-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-47 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D455-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D455-03 |
| filingDate | 1971-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1973-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1341109-A |
| titleOfInvention | Benzocycloheptaisoquinoline derivatives |
| abstract | 1341109 Benzocyclohepta - (pyrrolo-, pyrido- or azepino-) isoquinolines AYERST McKENNA & HARRISON Ltd 19 April 1971 [10 Feb 1970 21 Dec 1970] 21427/71 Heading C2C The invention comprises compounds of formulµ and acid addition salts of compounds (I), wherein Alk is -(CR 2 ) 3-5 - (Ia) or -CR<SP>11</SP> 2 -CHRCYZ-CR 2 - (joined to N by CR<SP>11</SP> 2 ) (Ib); R, R<SP>1</SP> and R<SP>11</SP> are each H or alkyl; Y is H, OH or C 2-10 -alkanoyloxy; Z is H, alkyl, alkenyl, alkynyl, C 3-6 -cycloalkyl, alkyl-C 3-6 -cycloalkyl or PhiX is an anion; and each alkyl, alkenyl or alkynyl contains up to 7 C atoms. The invention comprises also a specific ethylenedithioketal of the type indicated under reaction 3(b), below. In examples, (1) the alcohols (Ib : Y= OH) are prepared by reacting the corresponding ketones (CYZ=CO) with an organometallic reagent containing a Z radical, or by reducing the ketones, e.g. with NaBH 4 (when Z=H); (2) the alcohols are esterified with alkanoic acid anhydride; (3) Ia are prepared by (a) dehydrating the alcohols followed by hydrogenation; (b) reacting the ethylene dithioketals of the said ketones with Raney Ni; (c) reducing IV, or reacting IV with alkylmagnesium halide; (4) IV are prepared by reacting (a) a 5-(omegachloro- or hydrozy - alkanamidomethyl)-10,11- dihydro - 5H - dibenzo [a, d] cycloheptene with POCl 3 ; (b) a 5-(2-oxocyclopolymethyleneiminomethyl) - 10,11 - dihydro - 5H - dibenzo [a, d] cycloheptene with POCl 3 ; (c) Ia with Hg(OAc) 2 , followed by HCl. Different stereoisomeric forms of Ia may be isolated, depending upon the reducing agent employed in method 3(c). Starting materials also prepared are 5-hydroxy- 5-methoxymethyl-, and 5-formyl-10,11-dihydro- 5H-dibenzo [a, d] cycloheptene; and the 2,4- dinitrophenylhydrazone of the latter. Therapeutic compositions for oral or parenteral administration comprise the above compounds (I), which have C.N.S. depressant, anticonvulsant and anti-inflammatory activity. |
| priorityDate | 1970-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 35.