http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-1340894-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f88f84fc279fe5d0b9b5ec3c88c2e2b2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-08 |
| filingDate | 1971-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1973-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-1340894-A |
| titleOfInvention | Substituted piperazines |
| abstract | 1340894 2 - (2 - Aminoethyl) - piperazines A H ROBINS CO Inc 20 April 1971 [27 April 1970] 10219/71 Heading C2C Novel 2 - (2 - aminoethyl) - piperazines of the general formula wherein R is a hydrogen atom or a C 1-8 alkyl, C 3-9 cycloalkyl or phenyl-C 1-8 alkyl group, R<SP>1</SP> is a phenyl, C 1-8 alkylphenyl, di-C 1-8 alkylphenyl, C 1-8 alkoxyphenyl, halophenyl, trifluoromethylphenyl, C 1-8 alkylhalophenyl or 1-naphthyl group, Z is an ethylene or oxalyl group and Am is an amino group, and pharmaceutically acceptable acid addition salts thereof are prepared (a) when R is not a hydrogen atom and Z is an oxalyl group, by reaction of a 2-(2-haloethyl)-piperazine of the general formula wherein X is a halogen atom, with an amine of the general formula AmH; (b) when R is not a hydrogen atom and Z is an ethylene group, by treatment of the corresponding compound in which Z is an oxalyl group with lithium aluminium hydride; and (c) when R is a hydrogen atom, by debenzylation of the corresponding compound in which R is a benzyl group; followed optionally by salification of the product. Pharmaceutical compositions having antiviral activity comprise, as active ingredient, a 2-(2- amino-ethyl)-piperazine of the first general formula above or a pharmaceutically acceptable acid addition salt thereof, together with a pharmaceutically acceptable carrier, and may be administered orally or parenterally. |
| priorityDate | 1970-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 21.