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filingDate 1971-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1973-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber GB-1337178-A
titleOfInvention Blood serum analytical control standard
abstract 1337178 Blood serum control standard BAXTER LABORATORIES Inc 1 June 1971 [1 June 1970] 18376/71 Heading B1X A control standard for the analytical determination of at least three blood serum components, comprising a mixture of the blood serum components the respective concentrations of which have been predetermined by random selection from a predetermined range of lowest to highest concentration levels of each component, the three components and their corresponding concentration ranges being included in the list below. In an example, pooled human serum is filtered and treated with cation exchange resin to reduce the sodium and potassium levels of the serum, tris buffer or lithium hydroxide being added to maintain the pH of the serum at its original value, the pH of the treated serum is adjusted to 6 to 6.5, the serum is analysed for the seventeen components listed, a range of lowest to highest level concentrations is established for each component on the basis of instrumentation parameters and clinical significance, concentration values within each range are randomly selected, components are added to the treated serum to adjust the concentrations of the respective component to these random values, and the serum is refiltered, placed in vials and lyophilized. The components and their lowest to highest concentration levels are as follows: sodium 130 to 165 mequiv/litre; potassium 3 to 8 mequiv/litre; chloride 105 to 130 mequiv/litre; phosphorus 3.0 to 15 mgm/100 ml; calcium 5 to 14 mgm/100 ml; blood urea nitrogen 11 to 20 mgm/100 ml; uric acid 5 to 12 mgm/100 ml; creatinine 1 to 7 mgm/100 ml; glucose 65 to 400 mgm/100 ml; cholesterol 165 to 275 mgm/100 ml; bilirubin 0.5 to 2 mgm/100 ml; total protein 5.5 to 7.2 gm/100 ml; lactic dehydrogenase, 400 to 2400 spectrophotometric units; amylase 65 to 400 Somogyi units; acid phosphatase 0.4 to 3 Bessey-Lowry-Brock units; alkaline phosphatase 1.5 to 7 Bessey-Lowry-Brock units; protein-bound iodine 4.8 to 10.2 microgms/100 ml.
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